Open AccessJournal Article
Acute tubulointerstitial nephritis-uveitis (TINU) syndrome developed secondary to paracetamol and codeine phosphate use: two case reports.
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TLDR
Two adolescent cases of TIN and TINU, seemingly developed secondary to paracetamol and codeine phosphate use, are presented.Abstract:
Tubulointerstitial nephritis (TIN) refers to a group of heterogeneous diseases affecting the interstitial compartment of the kidney. It might be primary or can develop secondary to many urinary systemic diseases. Primary TIN develops mainly following drug usage, exposure to toxins, and also infections and humoral and cell-mediated immune reactions. In some patients, signs of systemic inflammatory reactions can be the first presenting symptoms. Histopathological evaluation reveals mononuclear cells and lymphocytes in the interstitium and tubuli. Acute and chronic TIN can resolve after elimination of the culprit destructive factors, as drugs, toxins and immune reaction. Combination of tubulointerstitial inflammation and uveitis is termed as tubulointerstitial nephritis-uveitis (TINU) syndrome. Uveitis might occur before, after, and also concomitantly with TIN. Herein, two adolescent cases of TIN and TINU, seemingly developed secondary to paracetamol and codeine phosphate use, are presented.read more
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Journal ArticleDOI
Drug-induced uveitis.
TL;DR: Ophthalmologists must recognize that drugs such as ICPIs, BRAF, and MEK inhibitors, anti-vascular endothelial growth factor agents, tumor necrosis factor-&agr; inhibitors, cidofovir, bisphosphonates, topical prostaglandin analogues, topical brimonidine, BCG vaccination can cause of uveitis.
Journal ArticleDOI
The Syndrome of Tubulointerstitial Nephritis With Uveitis (TINU).
David M. Clive,Vijay K. Vanguri +1 more
TL;DR: Owing to its low prevalence, no standard therapeutic protocols have been established, but most reported cases have been treated with corticosteroids or other immunomodulatory agents.
Journal ArticleDOI
Clinicopathologic characteristics, treatment, and outcomes of tubulointerstitial nephritis and uveitis syndrome in adults: A national retrospective strobe-compliant study
Mathieu Legendre,Hervé Devilliers,Laurent Perard,Matthieu Groh,Habdelamid Nefti,Bertrand Dussol,Salim Trad,Fatouma Touré,Sébastien Abad,Jean-Jacques Boffa,Luc Frimat,Stéphane Torner,Alexandre Seidowsky,Ziad A. Massy,David Saadoun,Virginie Rieu,Yoland Schoindre,Emmanuel Héron,Thierry Frouget,Arnaud Lionet,François Glowacki,Laurent Arnaud,Christiane Mousson,Jean-François Besancenot,Jean-Michel Rebibou,Philip Bielefeld +25 more
TL;DR: It is suggested that oral corticosteroids are effective for the treatment of TINU syndrome's uveitis, and 32% of patients were suffering from moderate to severe chronic kidney disease after 1 year of follow-up, and 40% had Uveitis relapses during this follow- up.
Journal ArticleDOI
Tubulointerstitial nephritis and uveitis syndrome: a systematic review.
Alessia Regusci,Sebastiano A. G. Lava,Gregorio P. Milani,Gregorio P. Milani,Mario G. Bianchetti,Giacomo D. Simonetti,Federica Vanoni +6 more
TL;DR: In this paper, a systematic review of the literature on cases of tubulointerstitial nephritis and uveitis (TINU) syndrome was conducted, where the authors investigated differences between males/females and pediatric and adult cases to identify potential risk factors for chronic kidney disease development.
Journal ArticleDOI
HLA-DQA1, -DQB1, and -DRB1 alleles associated with acute tubulointerstitial nephritis in a Chinese population: a single-center cohort study.
Yan Jia,Tao Su,Yanghui Gu,Cui Li,Xu-jie Zhou,Jianqun Su,Pingping Sun,Jiawei Tang,Liu Yang,Gang Liu,Li Yang +10 more
TL;DR: HLA-DQA1*0104/DQB1*0503/DRB1*1405 serves as a significant risk haplotype for development of D-ATIN and TINU, which might facilitate renal tubulointerstitial inflammation by enhancing Ag-presenting capacity of renal tubular cells.
References
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Journal ArticleDOI
Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis
Esther González,E. Gutiérrez,Cristina Galeano,C. Chevia,P. de Sequera,Carmen Bernis,E.G. Parra,R. Delgado,M. Sanz,M. Ortiz,Marian Goicoechea,C. Quereda,Teresa Olea,Hanane Bouarich,Y. Hernández,B. Segovia,Manuel Praga +16 more
TL;DR: S steroids should be started promptly after diagnosis of DI-AIN to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function, and a significant correlation between the delay in steroid treatment and the final serum creatinine is found.
Journal ArticleDOI
The changing profile of acute tubulointerstitial nephritis
Richard Baker,Charles D. Pusey +1 more
TL;DR: The widespread introduction of percutaneous renal biopsy led to the discovery of similar findings in association with drug-related renal failure, in particular related to the use of penicillins and sulphonamides, and ATIN is presumed to be immune-mediated.
Journal ArticleDOI
Acute interstitial nephritis: clinical features and response to corticosteroid therapy
Michael R. Clarkson,Louise Giblin,Fionnuala P. O'Connell,Patrick O'Kelly,J. Joseph Walshe,Peter J. Conlon,Yvonne M. O'Meara,Anthony Dormon,E. Campbell,John Donohoe +9 more
TL;DR: The results of this study do not support the routine administration of corticosteroid therapy in the management of AIN, and the largest retrospective series to date did not detect a statistically significant difference in outcome, as determined by serum creatinine, between those patients who received corticosterone therapy and those who did not, at 1, 6 and 12 months following presentation.
Journal ArticleDOI
The tubulointerstitial nephritis and uveitis syndrome.
TL;DR: TINU syndrome is a distinct clinical entity that may be under-recognized and may account for some cases of unexplained chronic or recurrent uveitis and it is important for ophthalmologists, nephrologists, and primary care providers to be familiar with this disorder to ensure early diagnosis and appropriate treatment.
Journal Article
Diagnosis and Management of Acute Interstitial Nephritis
Charles Kodner,Archana Kudrimoti +1 more
TL;DR: The time until removal of such agents, and renal biopsy findings, provide the best prognostic information for return to baseline renal function.