Institution
HCL Technologies
Company•Noida, Uttar Pradesh, India•
About: HCL Technologies is a company organization based out in Noida, Uttar Pradesh, India. It is known for research contribution in the topics: Population & Medicine. The organization has 1820 authors who have published 1502 publications receiving 34080 citations. The organization is also known as: HCL Technologies Limited & HCL Technologies Ltd.
Topics: Population, Medicine, Epilepsy, Cancer, Transplantation
Papers published on a yearly basis
Papers
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Stanford University1, HCL Technologies2, Universidad Mayor3, UCL Institute of Child Health4, University of Bonn5, University of California, Los Angeles6, Umeå University7, New York University8, Columbia University9, Yonsei University10, Albert Einstein College of Medicine11, University of Pavia12, University of Melbourne13, Karolinska Institutet14, University of Calgary15
TL;DR: A revised definition of epilepsy brings the term in concordance with common use for individuals who either had an age‐dependent epilepsy syndrome but are now past the applicable age or who have remained seizure‐free for the last 10 years and off antiseizure medicines for at least the last 5 years.
Abstract: Epilepsy was defined conceptually in 2005 as a disorder of the brain characterized by an enduring predisposition to generate epileptic seizures. This definition is usually practically applied as having two unprovoked seizures >24 h apart. The International League Against Epilepsy (ILAE) accepted recommendations of a task force altering the practical definition for special circumstances that do not meet the two unprovoked seizures criteria. The task force proposed that epilepsy be considered to be a disease of the brain defined by any of the following conditions: (1) At least two unprovoked (or reflex) seizures occurring >24 h apart; (2) one unprovoked (or reflex) seizure and a probability of further seizures similar to the general recurrence risk (at least 60%) after two unprovoked seizures, occurring over the next 10 years; (3) diagnosis of an epilepsy syndrome. Epilepsy is considered to be resolved for individuals who either had an age-dependent epilepsy syndrome but are now past the applicable age or who have remained seizure-free for the last 10 years and off antiseizure medicines for at least the last 5 years. "Resolved" is not necessarily identical to the conventional view of "remission or "cure." Different practical definitions may be formed and used for various specific purposes. This revised definition of epilepsy brings the term in concordance with common use. A PowerPoint slide summarizing this article is available for download in the Supporting Information section here.
3,491 citations
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TL;DR: This Clinical Practice Guideline presents updated recommendations for the optimal management of HBV infection, and future treatment strategies to achieve 'cure' of disease and new biomarkers are discussed.
3,016 citations
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TL;DR: In this paper, the root mean square strain was determined from the interplanar spacing and strain estimated from the three models, viz, uniform deformation model, unweighted deformation stress model, and uniform density model.
Abstract: ZnO nanoparticles were prepared by coprecipitation method at 450C. X-ray diffraction result indicates that the sample is having a crystalline wurtzite phase. Transmission electron microscopy (TEM) result reveals that the ZnO sample is spherical in shape with an average grain size of about 50nm. X-ray peak broadening analysis was used to evaluate the crystalline sizes and lattice strain by the Williamson-Hall (W-H) analysis. All other relevant physical parameters such as strain, stress, and energy density values were also calculated using W-H analysis with different models, viz, uniform deformation model, uniform deformation stress model and uniform deformation energy density model. The root mean square strain was determined from the interplanar spacing and strain estimated from the three models. The three models yield different strain values; it may be due to the anisotropic nature of the material. The mean particle size of ZnO nanoparticles estimated from TEM analysis, Scherrers formula and W-H analysis is highly intercorrelated.
1,439 citations
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TL;DR: The use of TDF-FTC before and after sexual activity provided protection against HIV-1 infection in men who have sex with men, and the treatment was associated with increased rates of gastrointestinal and renal adverse events.
Abstract: Background Antiretroviral preexposure prophylaxis has been shown to reduce the risk of human immunodeficiency virus type 1 (HIV-1) infection in some studies, but conflicting results have been reported among studies, probably due to challenges of adherence to a daily regimen.
Methods
We conducted a double-blind, randomized trial of antiretroviral therapy for preexposure HIV-1 prophylaxis among men who have unprotected anal sex with men. Participants were randomly assigned to take a combination of tenofovir disoproxil fumarate (TDF) and emtricitabine (FTC) or placebo before and after sexual activity. All participants received risk-reduction counseling and condoms and were regularly tested for HIV-1 and HIV-2 and other sexually transmitted infections.
Results
Of the 414 participants who underwent randomization, 400 who did not have HIV infection were enrolled (199 in the TDF-FTC group and 201 in the placebo group). All participants were followed for a median of 9.3 months (interquartile range, 4.9 to 20.6). A total of 16 HIV-1 infections occurred during follow-up, 2 in the TDF-FTC group (incidence, 0.91 per 100 person-years) and 14 in the placebo group (incidence, 6.60 per 100 person-years), a relative reduction in the TDF-FTC group of 86% (95% confidence interval, 40 to 98; P=0.002). Participants took a median of 15 pills of TDF-FTC or placebo per month (P=0.57). The rates of serious adverse events were similar in the two study groups. In the TDF-FTC group, as compared with the placebo group, there were higher rates of gastrointestinal adverse events (14% vs. 5%, P=0.002) and renal adverse events (18% vs. 10%, P=0.03).
Conclusions
The use of TDF-FTC before and after sexual activity provided protection against HIV-1 infection in men who have sex with men. The treatment was associated with increased rates of gastrointestinal and renal adverse events. (Funded by the National Agency of Research on AIDS and Viral Hepatitis [
ANRS] and others; ClinicalTrials.gov number, NCT01473472.)
1,226 citations
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TL;DR: MSH6 mutations are associated with markedly lower cancer risks than MLH1 or MSH2 mutations, and these risks do not increase appreciably until after the age of 40 years.
Abstract: 80%), 21% (95% CI, 8%-77%), and 16% (95% CI, 8%-32%). For ovarian cancer, they were 20% (95% CI, 1%-65%), 24% (95% CI, 3%-52%), and 1% (95% CI, 0%-3%). The estimated cumulative risks by age 40 years did not exceed 2% (95% CI, 0%-7%) for endometrial cancer nor 1% (95% CI, 0%-3%) for ovarian cancer, irrespective of the gene. The estimated lifetime risks for other tumor types did not exceed 3% with any of the gene mutations.
820 citations
Authors
Showing all 1826 results
Name | H-index | Papers | Citations |
---|---|---|---|
Gilles Salles | 99 | 854 | 48219 |
Fabien Zoulim | 96 | 641 | 35807 |
François Vandenesch | 83 | 407 | 32992 |
Vincent Cottin | 68 | 574 | 21594 |
Yves Rossetti | 67 | 251 | 13530 |
Philippe Ryvlin | 64 | 335 | 15024 |
Roland Chapurlat | 63 | 390 | 12656 |
Denis Fouque | 61 | 374 | 17101 |
Albert Eschenmoser | 60 | 320 | 12859 |
Bruno Lina | 59 | 394 | 12539 |
Charles Dumontet | 57 | 239 | 12402 |
Xavier Thomas | 57 | 365 | 12849 |
Prashant Singh | 56 | 365 | 27306 |
Olivier Glehen | 55 | 355 | 13946 |
Michael Muller | 55 | 475 | 13872 |