Showing papers in "Medicine in 2016"

TL;DR: According to the analysis, old men plus gastric fundus or antrum of CFB were strongly suggested to perform ESD if precancerous lesions were found and young women with low-grade intraepithelial neoplasia could select regular follow-up.

TL;DR: Although rare, this diagnosis is worth knowing, as specific treatment has to be started as soon as possible and proved to be efficient in this case as well as in other reports in the literature.

TL;DR: A systematic review and meta-analysis aimed to compare the discriminative ability of Child–Pugh versus MELD score to assess the prognosis of cirrhotic patients and found that their benefits might be heterogeneous in some specific conditions.

TL;DR: Gene oncology analysis revealed that hsa_circ_0005075 could participate in cell adhesion during HCC development and was identified as a potential HCC biomarker; however, further studies are required to confirm the role of this circRNA, and others, in H CC development.

TL;DR: Sarcopenia is an independent predictive factor of severe postoperative complications after radical gastrectomy for gastric cancer and is independently associated with overall and disease-free survival in patients with TNM stage II and III, but not in patientsWith TNM stages II and I, and under the adjusted tumor-node-metastasis (TNM) stage.

TL;DR: Several different approaches to treatment aimed at overcoming the intrinsic resistance of CSCs to conventional therapies are currently being developed, including agents targeting tumorigenic pathways, and immunotherapies, including vaccines and natural killer cells employed to induce a T cell response.

TL;DR: CSCs are a relatively rare population of cancer cells capable of self-renewal, differentiation, and generation of serially transplantable heterogeneous tumors of several types of cancer.

TL;DR: It is suggested that ICU professionals may suffer from a high level of burnout, potentially threatening patient care and future work should address the effective management of the factors negatively affecting ICu professionals.

TL;DR: The threshold for optimal adherence to achieve better virologic outcomes appears to be wider than the commonly used cut-off point (≥95% adherence), which could be redefined to a slightly lower level to encourage the prescribing ART at an early stage of HIV infection.

TL;DR: Increased understanding of the factors that create and contribute to tumor heterogeneity may support the design of therapies that affect CSC function and their microenvironments.

TL;DR: This review presents the results of articles relevant to age-related macular degeneration (AMD), diabetic retinopathy (DR), and OCT-A, a new promising method that allows the visualization of the retinal vascular network and the counting of blood flow parameters.

TL;DR: High prevalences of mental disorders in the CWS were reported, which highlights the need for the provision of qualified service and the substantial heterogeneity of the findings is indicative of theneed for accurate epidemiological data to effectively guide public policy.

TL;DR: Probiotics are safe and appear to exert some beneficial effects in GI-related illnesses, but the use of probiotics in non-GI illnesses is not sufficiently supported by current data.

TL;DR: The results support the evaluation of BRCA mutational status in patients with high risk of harboring BRCa germline mutations to better define the prognosis of breast cancer in these patients.

TL;DR: In this paper, the authors systematically reviewed data from randomized controlled trials (RCTs) to investigate the effect of probiotic consumption on respiratory tract infections (RTIs) in children.

TL;DR: Overall, PCOS in pregnancy was associated with greater risk of GDM, preeclampsia, PIH, preterm delivery, cesarean delivery, miscarriage, hypoglycemia, and perinatal death, and subgroup analysis suggested that these associations might be influenced by study design and pre-BMI.

TL;DR: An easy to use diagnostic scoring tool for NHL development in the context of SS is presented, and this model is highly significant for the design of early therapeutic interventions in high risk SS patients for NHLDevelopment.

TL;DR: Compared to non-TNBC, TNBC is larger and higher grade, but less likely to have lymph node metastases, and in a multivariable analysis controlling for tumor size and grade, T NBC was associated with significantly less node-positivity.

TL;DR: The increased risk of MI and coronary death associated with depression was consistent using modified inclusion criteria, across most subgroups, and after adjusting for possible publication bias.

TL;DR: IgG4-RD is a distinctive, unique, and treatable cause of large-vessel vasculitis that can also involve blood vessels secondary to perivascular tumefactive lesions and respond well to B cell depletion therapy.

TL;DR: In this paper, the authors performed a meta-analysis to investigate whether Chlamydia trachomatis infection increases the risk of cervical cancer and found that individuals infected with C. trachmatis have a higher risk of cancer.

TL;DR: Plasma uromodulin serves as a robust biomarker for kidney function and uniquely allows the identification of early stages of CKD and potentially solves the problem of creatinine-blind range of CKd, in which kidney impairment often remains undetected.

TL;DR: Wide heterogeneity was observed with respect to the first-line therapeutic approaches used for the different organ-specific disease subsets, including significant differences in the mean dose of glucocorticoids used.

TL;DR: The findings based on population-based cohort studies indicate that diabetes is associated with increased PD risk by about 38%.

TL;DR: This study suggested that ERAS was as safe as CPC and improved recovery of patients undergoing PD, thus reducing in-hospital costs and general adoption of ERAS protocols during PD should be recommended.

TL;DR: It is indicated that overweight is associated with a lower risk of all-cause mortality among patients with COPD whereas underweight isassociated with a higher risk ofall-cause death in these patients.

TL;DR: It is concluded that humoral, nonspecific immunity (phagocytic activity and oxidative burst), and the IL-6 are influenced in patients with iron deficiency anemia.

TL;DR: A number of studies have begun to elucidate the roles of immune cell subtypes and their capacity to function or dysfunction in the tumor microenvironment of PC, and immune therapy for PC becomes a clinical reality.

TL;DR: A meta-analysis examining the association of isocitrate dehydrogenase (IDH)1/2 mutations with overall survival (OS) and progression-free survival (PFS) in patients with glioblastomas indicated that the presence of IDH mutations was associated with better OS and PFS.

TL;DR: POEM represents a safe and efficacy procedure comparable to the safety profile of LHM for achalasia at a short-term follow-up, and long-term clinical trials are urgently needed.