Journal ArticleDOI
Adenyl cyclase and hormone action III. Calcium requirement for ACTH stimulation of adenyl cyclase
Hans-Peter Bär,Oscar Hechter +1 more
TLDR
ACTH sensitivity of adenyl cyclase in mitochondrial and microsomal fractions from bovine adrenal cortex and in ghosts from rat fat cells can be abolished by the Ca complexing agent EGTA and restored by addition of Ca, which may regulate 3′,5′-AMP formation both in the absence and presence of hormones.About:
This article is published in Biochemical and Biophysical Research Communications.The article was published on 1969-06-06. It has received 112 citations till now. The article focuses on the topics: Cyclase activity & Cyclase.read more
Citations
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Journal ArticleDOI
Stimulation of intestinal mucosal adenyl cyclase by cholera enterotoxin and prostaglandins
TL;DR: It is concluded that CT and certain prostaglandins produce small intestinal fluid secretion by increasing mucosal adenyl cyclase activity, thereby stimulating an active secretory process.
Journal ArticleDOI
Gonadotropin binding and stimulation of cyclic adenosine 3': 5' monophosphate and testosterone production in isolated Leydig cells
TL;DR: Gonadotropin binding and stimulation of cyclic adenosine 3':5'-monophosphate (cyclic AMP) formation and testosterone synthesis were studied in collagenase-dispersed interstitial cells from the adult rat testis Binding data were consistent with the presence of a single order of receptors, with no interaction between binding sites as mentioned in this paper.
Journal ArticleDOI
Chemical messengers in development: a hypothesis.
TL;DR: The hypothesis presented here suggests that simple derivatives of metabolites, including neurotransmitters and cyclic nucleotides, are linked together as regulatory molecules throughout the eukaryotes and are suggested to have a more general role in information transmission in eucaryotes than is generally accepted.
Book ChapterDOI
The structure and function of intercellular junctions in cancer.
TL;DR: Additional research is required to define the contribution of tumor gene products to the pathogenesis of junctional abnormalities in tumors and to elucidate the roles, if any, of these cell membrane defects in malignant growth.
Book ChapterDOI
Concentrations of Metabolites and Binding Sites. Implications in Metabolic Regulation
Alberto Sols,R. Marco +1 more
TL;DR: This chapter discusses the implications in metabolic regulation because of the concentrations of metabolites and binding sites in the eukaryotic cell of higher organisms, in which practically all important metabolic reactions occur.
References
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Journal ArticleDOI
Some Aspects of the Biological Role of Adenosine 3',5'-monophosphate (Cyclic AMP)
TL;DR: The evidence presented supports the hypothesis that the positive inotropic response to the catecholamines is mediated by cyclic AMP.
Journal ArticleDOI
Metabolism of Isolated Fat Cells V. PREPARATION OF "GHOSTS" AND THEIR PROPERTIES; ADENYL CYCLASE AND OTHER ENZYMES
TL;DR: Adenyl cyclase activity was found in ghosts and in a particulate fraction containing mitochondria released during lysis of fat cells, the effect of the hormone being greater on ghosts.
Journal ArticleDOI
The need for the presence of calcium for the stimulation in vitro of rat adrenal glands by adrenocorticotrophic hormone.
Journal ArticleDOI
Contrasting requirements for the lipolytic action of corticotropin and epinephrine on adipose tissue in vitro.
TL;DR: The lipolytic activities of ACTH and epinephrine were compared in order to determine whether they were similarly influenced by changes in the composition of the incubating media.
Journal ArticleDOI
Studies on the adrenocorticotropic hormone-activated adenyl cyclase of a functional adrenal tumor.
TL;DR: An adrenocorticotropic hormone (ACTH)-sensitive, steroid-producing mouse adrenal tumor was homogenized and fractionated by differential centrifugation and adenyl cyclase activity that was stimulated by ACTH and by fluoride was purified 10- to 20-fold and localized to particulate fractions.