Journal ArticleDOI
Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions
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This article is published in Periodontology 2000.The article was published on 1997-06-01. It has received 1016 citations till now.read more
Citations
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Journal ArticleDOI
Periodontitis: a polymicrobial disruption of host homeostasis
TL;DR: The interaction of the host immune system with the oral bacteria in healthy states and in diseased states is described and disease may result from 'community-based' attack on the host.
Journal ArticleDOI
Case Definitions for Use in Population-Based Surveillance of Periodontitis
Roy C. Page,Paul I. Eke +1 more
TL;DR: This classification defines severeperiodontitis and moderate periodontitis in terms of PD and CAL to enhance case definitions and further demonstrates the importance of thresholds ofPD and CAL and the number of affected sites when determining prevalence.
Case Definitions for Use in Population-Based Surveillance
TL;DR: The classification currently accepted by the American Academia of Periodontology (AAP) was devised by the 1999 Inter- national Workshop for a Classification of periodontal Diseases and Conditions as mentioned in this paper.
Journal ArticleDOI
Update of the Case Definitions for Population‐Based Surveillance of Periodontitis
TL;DR: Total periodontitis using the case definitions in this study should be based on the sum of mild, moderate, and severeperiodontitis.
References
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Journal ArticleDOI
Periodontal Disease and Cardiovascular Disease
TL;DR: It is suggested that periodontal disease, once established, provides a biological burden of endotoxin (lipopolysaccharide) and inflammatory cytokines (especially TxA2, IL-1β, PGE2, and TNF-α) which serve to initiate and exacerbate atherogenesis' and thromboembolic events.
Journal ArticleDOI
Periodontal Infection as a Possible Risk Factor for Preterm Low Birth Weight
Steven Offenbacher,Vern Katz,Gregory Fertik,John A. Collins,Doryck Boyd,Doryck Boyd,Gayle Maynor,Rosemary G. McKaig,James D. Beck +8 more
TL;DR: It is demonstrated that periodontal disease is a statistically significant risk factor for PLBW with adjusted odds ratios of 7.9 and 7.5 for all PLBW cases and primiparous PL BW cases, respectively.
Journal ArticleDOI
The interleukin-1 genotype as a severity factor in adult periodontal disease
Kenneth S. Kornman,Allison Crane,Hwa-Ying Wang,Francesco S.di Giovlne,Michael G. Newman,Frederick W. Pirk,Thomas G. Wilson,Frank L. Higginbottom,Gordon W. Duff +8 more
TL;DR: It is demonstrated that specific genetic markers, that have been associated with increased IL-1 production, are a strong indicator of susceptibility to severe periodontitis in adults.
Journal ArticleDOI
Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria.
William McGuire,Adrian V. S. Hill,Catherine E. M. Allsopp,Brian Greenwood,Dominic P. Kwiatkowski +4 more
TL;DR: The maintenance of the TNF2 allele at a gene frequency of 0.16 in The Gambia implies that the increased risk of cerebral malaria in homozygotes is counterbalanced by some biological advantage, suggesting that regulatory polymorphisms of cytokine genes can affect the outcome of severe infection.