Aggressive form of pleural epithelioid haemangioendothelioma : complete response after chemotherapy
TLDR
This study describes a case of bilateral pleural epithelioid haemangioendothelioma that extended to the peritoneum that was confirmed by both conventional examination and immunohistochemistry and a complete response was obtained.Abstract:
Epithelioid haemangioendotheliomas are rare tumours of endothelial origin. They can develop in any tissue but occur principally in the lung and liver. Their usual course is a slow progression, so that they can be treated by surgery. In aggressive forms, no treatment has proved efficient to date. This study, describes a case of bilateral pleural epithelioid haemangioendothelioma that extended to the peritoneum. The histological diagnosis was confirmed by both conventional examination and immunohistochemistry. After six courses of carboplatine plus etoposide, a complete response was obtained. The complete remission is still lasting at 18 months after the diagnosis and the patient is healthy.read more
Citations
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Epithelioid Hemangioendothelioma: An Overview and Update on a Rare Vascular Tumor
TL;DR: Evidence is in favor of radiotherapy which offers local pain control with good tolerance and better quality of life at least at a one-year follow-up in most of cases, and further studies are needed to establish the standard radiation dose to be used for locoregional control of such a complex and extremely rare disease.
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Prognostic factors and surgical indications of pulmonary epithelioid hemangioendothelioma: a review of the literature.
P. Bagan,Mohammed Hassan,Françoise Le Pimpec Barthes,Séverine Peyrard,R. Souilamas,Claire Danel,Marc Riquet +6 more
TL;DR: Pulmonary epithelioid hemangioendothelioma typically occurs among young patients, and loss of weight, anemia, pulmonary symptoms, and more particularly pleural hemorrhagic effusions were significant factors of poor prognosis.
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Pulmonary Epithelioid Hemangioendothelioma: An Unusual Case and a Review of the Literature
Paul Cronin,Douglas A. Arenberg +1 more
TL;DR: In this article, a case of pulmonary epithelioid hemangioendothelioma, previously known as intravascular bronchoalveolar tumor, was described in a 35-year-old woman with an initial diagnosis made by transbronchial biopsy.
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Epithelioid Hemangioendothelioma: Update on Diagnosis and Treatment.
Ari Rosenberg,Mark Agulnik +1 more
TL;DR: There is evidence to support the use of chemotherapeutics and targeted therapies specifically focusing on anti-angiogenesis, and the current landscape of oncology with the emergence and excitement of immunotherapy could also translate in a role for immunotherapy in this disease.
Journal ArticleDOI
Pleural Epithelioid Hemangioendothelioma
Young Joo Lee,Moon Jae Chung,Ki Cheon Jeong,Chang Hoon Hahn,Ki Pyo Hong,Yee Jeong Kim,Yong Tai Kim +6 more
TL;DR: A rare case of pleural EHE extending to lung and bone in a 31-year-old woman who survived for 10 months after the diagnosis, confirmed by both conventional examination and immunohistochemistry.
References
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Epithelioid hemangioendothelioma of the liver: a clinicopathologic study of 137 cases.
TL;DR: Epithelioid hemangioendothelioma is a rare neoplasm of vascular origin that occurs in the liver and other organs; its etiology is unknown.
Journal Article
Endothelial Cell Markers CD31, CD34, and BNH9 Antibody to H- And Y-antigens--evaluation of Their Specificity and Sensitivity in the Diagnosis of Vascular Tumors and Comparison With Von Willebrand Factor
TL;DR: Sixty vascular tumors including 23 angiosarcomas, 300 nonvascular tumors, and selected normal tissues were immunohistochemically evaluated with antibodies to CD31, CD34, and von Willebrand factor, and monoclonal antibody BNH9, to test the sensitivity and specificity of these markers in the identification of endothelial cells and vascular tumors.
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Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor.
David H. Dail,Averill A. Liebow,John T. Gmelich,Paul J. Friedman,Katsumi Miyai,Werner Myer,Susan D. Patterson,Samuel P. Hammar +7 more
TL;DR: Twenty cases of an unusual tumor of the lung are described, which is a peculiar sclerosing tumor of endothelial cell origin that presents with multiple small, slowly growing pulmonary nodules.
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Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression
Masanori Kitaichi,Sonoko Nagai,Koichi Nishimura,Harumi Itoh,Asamoto H,Takateru Izumi,DH Dail +6 more
TL;DR: This investigation studied the general conditions and prognostic factors of pulmonary epithelioid haemangioendothelioma, which is a rare disease, and three patients demonstrated partial spontaneous regression, and adverse prognostic features were identified.
Journal ArticleDOI
Hepatic epithelioid hemangioendothelioma.
TL;DR: Computed tomographic findings suggest the tumor begins as multiple hepatic nodules that grow and coalesce, forming large confluent masses preferentially involving the liver periphery, which is associated with enlargement of uninvolved portions of the liver and splenomegaly.