Journal ArticleDOI
Aggressiveness by isolation and brain serotonin turnover changes in different strains of mice.
Luigi Valzelli,Sergio Bernasconi +1 more
TLDR
Brain serotonin turnover varies significantly only in those strains which react to isolation with a constant degree of aggressiveness and there appears to exist an inverse correlation between these two parameters.Abstract:
In the framework of aggressive behavior a great amount of studies deal with altered brain monoamine levels or turnover. The involvement of brain serotonergic mechanisms in aggression has been demonstrated in the majority of the studies. In the present work, the biochemical and behavioral changes induced by prolonged socioenvironmental isolation in seven strains of mice were studied. Brain serotonin turnover varies significantly only in those strains which react to isolation with a constant degree of aggressiveness and there appears to exist an inverse correlation between these two parameters. Nevertheless a certain degree of aggression may develop even in the absence of alterations of brain serotonin turnover. Still the intensity of serotonin turnover decrease seems to represent a good indicator of the magnitude of the aggressive reaction.read more
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Journal ArticleDOI
Serotonergic Studies in Patients with Affective and Personality Disorders: Correlates with Suicidal and Impulsive Aggressive Behavior
Coccaro Ef,Larry J. Siever,Howard Klar,Gail Maurer,Karen Cochrane,Thomas B. Cooper,Richard C. Mohs,Kenneth L. Davis +7 more
TL;DR: It is suggested that reduced central serotonergic function is present in a subgroup of patients with major affective and/or personality disorder and is associated with history of suicide attempt in patients with either disorder, but with impulsive aggression in Patients with personality disorder only.
Journal ArticleDOI
Reconciling the role of central serotonin neurons in human and animal behavior
TL;DR: Whether anxiety reduction or increased impulsivity is more likely to account for animal behavioral changes associated with decreased serotonergic transmission is investigated, as well as the effects of manipulating central serotonin in experimental anxiety paradigms in animals (punishment, extinction, novelty).
Journal ArticleDOI
Central serotonin and impulsive aggression.
TL;DR: Preliminary data with the 5- HT receptor agonist m-chlorophenylpiperazine suggest that reduced activity of post-synaptic 5-HT receptors may be an important correlate of impulsive aggressive behaviour in psychiatric patients.
Journal ArticleDOI
Self-injurious behavior: a review of the behavior and biology of self-mutilation.
Ronald Winchel,Michael Stanley +1 more
TL;DR: Although no form of treatment has yet been demonstrated to be of general benefit, the literature suggests that therapeutic trials with dopamine antagonists, serotonin reuptake inhibitors, and opiate antagonists may be of value.
Journal ArticleDOI
Aggressive behavioral phenotypes in mice.
TL;DR: While changes in aggression characterize mutant mice involving a variety of genes, no pattern has emerged that links particular gene products to either an increase or a decrease in aggressive behavior, but rather emphasizes polygenic influences.