Journal ArticleDOI
Alkylation of amino acids without loss of the optical activity: preparation of .alpha.-substituted proline derivatives. A case of self-reproduction of chirality
Reads0
Chats0
TLDR
In this article, an enolate par condensation de proline avec le pivalaldehyde suivie de deprotonation is described. André et al. describe the reactions of this enolate avec divers electrophiles.Abstract:
Preparation d'un enolate par condensation de proline avec le pivalaldehyde suivie de deprotonation. Etude des reactions de cet enolate avec divers electrophiles. Condensation du pivalaldehyde avec d'autres aminoacidesread more
Citations
More filters
Journal ArticleDOI
Proline-Catalyzed Direct Asymmetric Aldol Reactions
TL;DR: The finding that the amino acid proline is an effective asymmetric catalyst for the direct aldol reaction between unmodified acetone and a variety of aldehydes is reported.
Journal ArticleDOI
Structure and Reactivity of Lithium Enolates. From Pinacolone to Selective C‐Alkylations of Peptides. Difficulties and Opportunities Afforded by Complex Structures
TL;DR: The chemistry of lithium enolates is used to demonstrate that complex structures held together by noncovalent bonds (supramolecules) may dramatically influence the result of seemingly simple standard reactions of organic synthesis as mentioned in this paper.
Journal ArticleDOI
Stereoselective synthesis of quaternary α-amino acids. Part 1: Acyclic compounds
Journal ArticleDOI
Chiral heterocycles by iminium ion cyclization.
Journal ArticleDOI
Total synthesis of (+)-11,11'-dideoxyverticillin A.
TL;DR: This work reports a concise enantioselective total synthesis of (+)-11,11′-dideoxyverticillin A via a strategy inspired by the biosynthetic hypothesis for this alkaloid through a rapid functionalization of the advanced molecular framework.
Related Papers (5)
Enantioselective Generation and Diastereoselective Reactions of Chiral Enolates Derived from α-Heterosubstituted Carboxylic Acids. Preliminary Communication
Dieter Seebach,Reto Naef +1 more
N,O-acetals from pivalaldehyde and amino acids for the α-alkylation with self-reproduction of the center of chirality: enolates of 3-benzoyl-2-(tert-butyl)-1,3-oxazolidin-5-ones
Dieter Seebach,Antoine Fadel +1 more