Journal ArticleDOI
Amiloride and the mode of action of aldosterone on sodium transport across toad bladder and skin
Jean Crabbé,Ehrlich En +1 more
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TLDR
The characteristics of the inhibitory influence exerted by amiloride on active sodium transport by toad bladder and skin were taken advantage of to shed additional light on the mechanism whereby hormones-chiefly aldosterone-stimulate sodium transport across such epithelia.Abstract:
The characteristics of the inhibitory influence exerted by amiloride on active sodium transport by toad bladder and skin were taken advantage of to shed additional light on the mechanism whereby hormones-chiefly aldosterone-stimulate sodium transport across such epithelia.read more
Citations
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Subcellular mechanisms in the action of adrenal steroids.
TL;DR: Understanding of receptor mechanisms, albeit incomplete, provides an explanation of steroid specificity and overlapping physiologic effects and enables us to design new and more potent steroid antagonists and to rationalize resistance or sensitivity of tumor cells to specific steroids.
Journal ArticleDOI
Na+ transport by rabbit urinary bladder, a tight epithelium
Simon A. Lewis,Jared M. Diamond +1 more
TL;DR: The physiological significance of Na+ absorption against steep gradients in rabbit bladder may be to maintain kidney-generated ion gradients during bladder storage of urine, especially when the animal is Na+-depleted.
Journal ArticleDOI
Osmoregulation and excretion
Erik Larsen,Lewis E. Deaton,Horst Onken,Michael P. O'Donnell,Martin Grosell,William H. Dantzler,Dirk Weihrauch +6 more
TL;DR: How knowledge in these areas of comparative physiology has expanded considerably during the last two decades is demonstrated, bridging seminal classical works with studies based on new approaches at all levels of anatomical and functional organization.
Journal ArticleDOI
Effect of Changes in Transepithelial Transport on the Uptake of Sodium across the Outer Surface of the Frog Skin
TL;DR: The results support the view proposed previously that the sodium uptake is made up of two components, a linear component which is, essentially, not involved in transepithelial movement of sodium and a saturating component which reflects changes in tranzapithelial transport.
Journal ArticleDOI
Effect of amiloride and some of its analogues of cation transport in isolated frog skin and thin lipid membranes.
TL;DR: The inhibition of short-circuit current in isolated frog skin and the induction of surface potentials in lipid bilayer membranes produced by the diuretic drug amiloride and a number of its chemical analogues was studied.
References
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Journal ArticleDOI
Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.
Hans H. Ussing,K. Zerahn +1 more
Journal ArticleDOI
Ion transport in isolated rabbit ileum. i. short-circuit current and na fluxes.
Stanley G. Schultz,Ralph Zalusky +1 more
TL;DR: It is demonstrated that the serosa-to-mucosa flux of Na may be attributed to passive diffusion with no evidence for the presence of carrier-mediated exchange diffusion or the influence of solvent-drag.
Journal ArticleDOI
Amiloride: a potent inhibitor of sodium transport across the toad bladder
TL;DR: Amiloride inhibits Na transport and short‐circuit current (SCC) across the toad bladder through mucosal and serosal channels and is 1000 times more active at the mucosal than serosal surface.
Journal ArticleDOI
Stimulation of active sodium transport by the isolated toad bladder with aldosterone in vitro
TL;DR: These investigators have shown that, when an external potential is applied so as to, aldosterone is the principle immediately responsible for renal sodium retention and the isolated toad bladder was thought suitable for a more direct examination of the stimulation of sodium reabsorption by ald testosterone.
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Active transport of sodium as the source of electric current in the short-circuited isolated frog skin.
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