Journal ArticleDOI
An atypical human alcohol dehydrogenase.
TLDR
A simple screening test is described to differentiate between atypical and normal alcohol dehydrogenase in liver homogenate.Abstract:
An atypical alcohol dehydrogenase was found in two human livers. The anomalous enzyme, which has been purified, differs from the normal regarding (a) pH rate profile, (b) substrate specificity, and (c) sensitivity to metal binding agents. Thiourea inhibits the variant enzyme, but activates normal human liver alcohol dehydrogenase. A simple screening test is described to differentiate between atypical and normal alcohol dehydrogenase in liver homogenate. Total alcohol dehydrogenase activity was considerably higher in livers containing the atypical enzyme.read more
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Book ChapterDOI
3 Alcohol Dehydrogenases
TL;DR: This chapter describes the advances with an emphasis on the structures of the alcohol dehydrogenases and the relationship between structure and function, and establishes that mammalian alcohol dehydrogensases have a distant evolutionary link to both the yeast and bacterial enzymes.
Journal ArticleDOI
Overview of the role of alcohol dehydrogenase and aldehyde dehydrogenase and their variants in the genesis of alcohol-related pathology
TL;DR: The strongest correlations found to date have been those between the ALDH2*2 allele and cancers of the oro-pharynx and oesophagus, and it will be important to replicate other interesting associations between these variants and other cancers and heart disease, and to determine the biochemical mechanisms underlying the associations.
Journal ArticleDOI
Ethanol metabolism, cirrhosis and alcoholism.
TL;DR: Polyenylphosphatidylcholine (PPC) fully prevents ethanol-induced septal fibrosis and cirrhosis, opposes ethanol- induced hepatic phospholipid depletion, decreased phosphatidylethanolamine methyltransferase activity and activation of hepatic lipocytes, whereas its dilinoleoyl species increases collagenase activity.
Journal ArticleDOI
Developmental changes and polymorphism in human alcohol dehydrogenase
TL;DR: Human alcohol dehydrogenase has been investigated by spectrophotometry assay and by starch‐gel electrophoresis and it is shown that the former is superior to the latter in terms of specificity and purity.
Journal ArticleDOI
Racial differences in alcohol sensitivity: A new hypothesis
TL;DR: The data suggest that the initial alcohol sensitivity in Japanese might be due to a delayed oxidation of acetaldehyde rather than its higher than normal production by atypical alcohol dehydrogenase.