Journal ArticleDOI
Ethanol metabolism, cirrhosis and alcoholism.
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TLDR
Polyenylphosphatidylcholine (PPC) fully prevents ethanol-induced septal fibrosis and cirrhosis, opposes ethanol- induced hepatic phospholipid depletion, decreased phosphatidylethanolamine methyltransferase activity and activation of hepatic lipocytes, whereas its dilinoleoyl species increases collagenase activity.About:
This article is published in Clinica Chimica Acta.The article was published on 1997-01-03. It has received 415 citations till now. The article focuses on the topics: Microsomal ethanol oxidizing system & Ethanol metabolism.read more
Citations
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The role of carotenoids in the prevention of human pathologies.
TL;DR: In this paper, the role of gap junctional communication between cells which may be a basis for protection against cancer development is independent of the antioxidant property of carotenoids, and increased intake of lycopene as the all-trans-isomer attenuates alcohol induced 2E1 cells and reduces risk of prostate, lung and digestive cancers.
Journal ArticleDOI
Mechanisms of liver fibrosis.
TL;DR: Many of the molecular events that occur following HSC activation and collagen gene regulation that contribute to the fibrogenic nature of these cells are described and a review of therapeutic strategies to treat this disease is provided.
Journal ArticleDOI
Metabolic Interactions of Alcohol and Folate
TL;DR: Chronic alcohol exposure impairs folate absorption by inhibiting expression of the reduced folate carrier and decreasing the hepatic uptake and renal conservation of circulating folate, while folate deficiency accelerates alcohol-induced changes in hepatic methionine metabolism while promoting enhanced oxidative liver injury and the histopathology of ALD.
Journal ArticleDOI
Alcohol, host defence and society
Steve Nelson,Jay K. Kolls +1 more
TL;DR: Both acute and chronic alcohol intake have been shown to result in specific defects in innate and adaptive immunity that could, in principle, be subjected to specific modulation to overcome the immunosuppressive effects of the most commonly abused substance in the Western world.
Journal ArticleDOI
Experimental models of liver fibrosis
Sara Crespo Yanguas,Bruno Cogliati,Joost Willebrords,Michaël Maes,Isabelle Colle,Bert Van Den Bossche,Claudia P. Oliveira,Wellington Andraus,Venâncio Avancini Ferreira Alves,Isabelle Leclercq,Mathieu Vinken +10 more
TL;DR: A state-of-the-art overview of in vivo and in vitro models used in the field of experimental liver fibrosis research is provided.
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Journal ArticleDOI
The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers
O.P. Heinonen,D. Albanes +1 more
TL;DR: No reduction in the incidence of lung cancer among male smokers is found after five to eight years of dietary supplementation with alpha-tocopherol or beta carotene, and this trial raises the possibility that these supplements may actually have harmful as well as beneficial effects.
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Methionine metabolism in mammals.
TL;DR: Article de synthese sur le metabolisme de la methionine, acide amine essentiel, chez les mammiferes, de la regulation du metabolisme (mise en evidence and importance relative of chaque facteur).
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High blood alcohol levels in women. The role of decreased gastric alcohol dehydrogenase activity and first-pass metabolism.
TL;DR: It is concluded that the increased bioavailability of ethanol resulting from decreased gastric oxidation of ethanol may contribute to the enhanced vulnerability of women to acute and chronic complications of alcoholism.
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Hepatic Microsomal Ethanol-oxidizing System: IN VITRO CHARACTERISTICS AND ADAPTIVE PROPERTIES IN VIVO
TL;DR: The existence of a microsomal ethanol-oxidizing system, especially its capacity to increase in activity adaptively after ethanol feeding, may explain various effects of ethanol, including proliferation of hepatic smooth endoplasmic reticulum, induction of other hepaticmicrosomal drug-detoxifying enzymes, and the metabolic tolerance to ethanol which develops in alcoholics.
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Ethanol Oxidation by Hepatic Microsomes: Adaptive Increase after Ethanol Feeding
TL;DR: Hepatic microsomes contain an ethanol-oxidizing system distinct from alcohol dehydrogenase that has characteristics comparable to those of microsomal drug-detoxifying enzymes and, in vivo, it is capable of adaptation to the administration of ethanol.