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Open AccessJournal ArticleDOI

An fMRI study of semantic processing in men with schizophrenia

TLDR
In patients with schizophrenia, LIFC underactivation and left superior temporal gyrus overactivation for semantically encoded words may reflect a disease-related disruption of a distributed frontal temporal network that is engaged in the representation and processing of meaning of words, text, and discourse and which may underlie schizophrenic thought disturbance.
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This article is published in NeuroImage.The article was published on 2003-12-01 and is currently open access. It has received 101 citations till now. The article focuses on the topics: Semantic memory & Levels-of-processing effect.

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Citations
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Journal ArticleDOI

The role of the cerebellum in schizophrenia.

TL;DR: Evidence indicating that the cerebellum plays a role in higher cortical functions is summarized and evidence indicating that cerebellar abnormalities occur in schizophrenia is reviewed to suggest interesting directions for future research.
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The Role of the Cerebellum in Schizophrenia: an Update of Clinical, Cognitive, and Functional Evidences

TL;DR: Functional models of the cerebellum are proposed as a background for interpreting research focusing on cerebellar dysfunctions in schizophrenia, and the picture arising from this review is heterogeneous.
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Prefrontal activation deficits during episodic memory in schizophrenia

TL;DR: The finding of prominent prefrontal dysfunction suggests that cognitive control deficits strongly contribute to episodic memory impairment in schizophrenia, and memory rehabilitation approaches developed for patients with frontal lobe lesions and pharmacotherapy approaches designed to improve prefrontal cortex function hold special promise for remediating memory deficits in patients with schizophrenia.
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The Cognitive Neuroscience of Memory Function and Dysfunction in Schizophrenia

TL;DR: A brief review of the significant progress that cognitive neuroscience has made in understanding basic mechanisms of episodic memory formation and retrieval that were presented and discussed at the first CNTRICS meeting in Washington, D.C.
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Episodic memory-related activation in schizophrenia: meta-analysis

TL;DR: Beneath the apparent heterogeneity of published findings on schizophrenia and memory, a consistent and robust pattern of group differences is observed as a function of memory processes.
References
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An integrative theory of prefrontal cortex function

TL;DR: It is proposed that cognitive control stems from the active maintenance of patterns of activity in the prefrontal cortex that represent goals and the means to achieve them, which provide bias signals to other brain structures whose net effect is to guide the flow of activity along neural pathways that establish the proper mappings between inputs, internal states, and outputs needed to perform a given task.
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Statistical parametric maps in functional imaging: A general linear approach

TL;DR: In this paper, the authors present a general approach that accommodates most forms of experimental layout and ensuing analysis (designed experiments with fixed effects for factors, covariates and interaction of factors).
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Levels of processing: A framework for memory research

TL;DR: This paper reviewed the evidence for multistore theories of memory and pointed out some difficulties with the approach and proposed an alternative framework for human memory research in terms of depth or levels of processing.
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Voxel-Based Morphometry—The Methods

TL;DR: In this paper, the authors describe the steps involved in VBM, with particular emphasis on segmenting gray matter from MR images with non-uniformity artifact and provide evaluations of the assumptions that underpin the method, including the accuracy of the segmentation and the assumptions made about the statistical distribution of the data.
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Positron emission tomographic studies of the cortical anatomy of single-word processing

TL;DR: The use of positron emission tomography to measure regional changes in average blood flow during processing of individual auditory and visual words provides support for multiple, parallel routes between localized sensory-specific, phonological, articulatory and semantic-coding areas.
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