Journal ArticleDOI
An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani
R.A. Neal,Simon L. Croft +1 more
TLDR
A method has been defined for infecting primary mouse peritoneal macrophages with amastigotes of Leishmania donovani in vitro, and analysing the response of the infected macrophage to treatment with drugs.Abstract:
A method has been defined for infecting primary mouse peritoneal macrophages with amastigotes of Leishmania donovani in vitro, and analysing the response of the infected macrophages to treatment with drugs. The growth of intracellular amastigotes was inhibited by all clinically used antileishmanial drugs. Toxic effects on macrophages were observed with some drugs. Other experimental antileishmanial compounds were active in this system. This test is proposed as an initial screening test for the discovery of novel antileishmanial compounds.read more
Citations
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Journal ArticleDOI
Drug Resistance in Leishmaniasis
TL;DR: It is essential that there be a strategy to prevent the emergence of resistance to new drugs; combination therapy, monitoring of therapy, and improved diagnostics could play an essential role in this strategy.
Journal ArticleDOI
A review of natural products with antileishmanial activity
L.G. Rocha,Jackson Roberto Guedes da Silva Almeida,Rui Oliveira Macêdo,José Maria Barbosa-Filho +3 more
TL;DR: A review of the literature on plant extracts and chemically defined molecules of natural origin showing antileishmanial activity and some aspects of recent antileishesmanial-activity-directed research on natural products are discussed.
Journal Article
Current scenario of drug development for leishmaniasis.
TL;DR: Alternative and potentially cheaper formulations of amphotericin B, alklyphosphocholines other than miltefosine and improved formulations of paromomycin for CL have been identified and drugs or compounds that have demonstrated activity in experimental rodent models of infection are identified.
Journal ArticleDOI
Mucosal leishmaniasis ("espundia" Escomel, 1911).
TL;DR: One of the more serious clinical forms of leishmaniasis occurs in espundia when the mucosae of the upper respiratory passages are inflamed, and specific treatment targeted to this specific problem is the efficient short term solution.
Journal ArticleDOI
Chemotherapy of leishmaniasis: past, present and future.
TL;DR: The present review describes the current understanding of different drugs against leishmaniasis, their chemistry, mode of action and the mechanism of resistance in the parasite.
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Leishmaniasis– current chemotherapy and recent advances in the search for novel drugs
Simon L. Croft,Graham H. Coombs +1 more