Journal ArticleDOI
Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm
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TLDR
Most likely it is a tumor of fibroblast‐ and histiocyte‐like cells, akin to malignant fibrous histiocytoma, but different in its age incidence, microscopic appearance, and behavior.Abstract:
This article describes 41 examples of an unusual fibrohistiocytic sarcoma which occurred primarily in the extremities of young individuals between the ages of 5 and 25 years (median 13 years). It manifested as a nodular subcutaneous growth that seldom caused tenderness or pain, and clinically was often mistaken for a hematoma or a hemangioma. Grossly, the tumor presented as a circumscribed, multinodular or multicystic, hemorrhagic mass that ranged in size from 0.7 to 10 cm (median 2.5 cm). On microscopic examination, it consisted principally of 1) solid arrays or nests of fibroblast- and histiocyte-like cells, not infrequently containing varying amounts of intracellular hemosiderin or lipid, 2) focal areas of hemorrhage or hemorrhagic cyst-like spaces, sometimes occupying the major portion of the tumor, and 3) aggregates of chronic inflammatory cells, chiefly lymphocytes and plasmacytes, a feature that caused confusion with a lymph node metastasis in several cases. Follow-up information, available in 24 patients, revealed a variable clinical course. Twenty-one patients were alive, 11 with recurrence (including one with 9 recurrences in a 21-year period) one with recurrence and metastasis and one with metastasis. Three patients had died of metastasis 1, 3, and 13 years respectively, after the initial surgical therapy. The exact histogenesis is still obscure. Most likely it is a tumor of fibroblast- and histiocyte-like cells, akin to malignant fibrous histiocytoma, but different in its age incidence, microscopic appearance, and behavior.read more
Citations
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Journal ArticleDOI
Recurrent painful perianal subcutaneous angiomatoid fibrous histiocytoma: a case report and review of the literature.
TL;DR: This case emphasizes the need to correctly diagnose soft-tissue tumors using a variety of diagnostic modalities to ensure that the patient receives proper treatment.
Journal ArticleDOI
Angiomatoid Fibrous Histiocytoma in the Forearm: A Case Report
Hatim Mohammed A Alshareef,Ahmed H. Alhasan,Mohammed G. Felemban,Ashwaq M. Almalki,Amer Mohammed A Alshareef +4 more
TL;DR: This tumor has a relatively rare metastasis and its overall clinical outcome is excellent, it is clinically important to accurately diagnose this tumor so that wide local excision may be performed and patients may be appropriately monitored and followed up.
Journal ArticleDOI
Tocilizumab Controls Paraneoplastic Inflammatory Syndrome but Does Not Suppress Tumor Growth of Angiomatoid Fibrous Histiocytoma.
Hideaki Sabe,Akitomo Inoue,Shigenori Nagata,Yoshinori Imura,Toru Wakamatsu,Satoshi Takenaka,Hironari Tamiya +6 more
TL;DR: In this paper, a case report on a patient with local recurrence and distant lymph node metastasis of angiomatoid fibrous histiocytoma (AFH) treated with tocilizumab showed that the inhibition of the IL-6 signaling pathway controlled paraneoplastic inflammatory syndrome (PIS), however, the local recurrent tumor progressed.
Journal ArticleDOI
Angiomatoid fibrous histiocytoma in the spinal canal of T3-T4: a case report and literature review
Jiangwei Ding,Gang Zhou,Yang Dong,Xinxiao Li,Lei Wang,Baorui Guo,Caibin Gao,Siying Xu,Feng Wang,Tao Sun +9 more
TL;DR: A rare case of AFH in the cervical canal of a 20-year-old male patient is reported, the first case in the spinal canal to be reported, and the diagnosis was confirmed by postoperative pathology.
References
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Journal ArticleDOI
Malignant fibrous histiocytoma: an analysis of 200 cases.
TL;DR: The clinicopathologic findings in 200 cases of malignant fibrous histiocytoma (MFH) with follow‐up information are presented and it is felt it is best regarded as a primitive and pleomorphic sarcoma showing partial fibroblastic and Histiocytic differentiation, as reflected by collagen production and occasional phagocytosis.
Journal ArticleDOI
Hemangiopericytoma. An analysis of 106 cases.
Franz M. Enzinger,Bruce H. Smith +1 more
TL;DR: The close resemblance of hemangiopericytoma to richly vascular forms of fibrous histiocytomas and synovial sarcoma is emphasized, and the morphologic differences from other mesenchymal tumors showing a hemango-like vascular pattern are discussed.
Journal ArticleDOI
Histiocytic tumors (fibrous xanthoma and histiocytoma) in children.
Journal ArticleDOI
Aneurysmal Sclerosing Hemangioma of Skin
TL;DR: Although both lesions were clinically alarming, they were histologically benign and no recurrence or metastasis has developed in either case in follow-up periods of 9 and 2½ years respectively.
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