Journal ArticleDOI
Angiomatoid malignant fibrous histiocytoma. A distinct fibrohistiocytic tumor of children and young adults simulating a vascular neoplasm
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TLDR
Most likely it is a tumor of fibroblast‐ and histiocyte‐like cells, akin to malignant fibrous histiocytoma, but different in its age incidence, microscopic appearance, and behavior.Abstract:
This article describes 41 examples of an unusual fibrohistiocytic sarcoma which occurred primarily in the extremities of young individuals between the ages of 5 and 25 years (median 13 years). It manifested as a nodular subcutaneous growth that seldom caused tenderness or pain, and clinically was often mistaken for a hematoma or a hemangioma. Grossly, the tumor presented as a circumscribed, multinodular or multicystic, hemorrhagic mass that ranged in size from 0.7 to 10 cm (median 2.5 cm). On microscopic examination, it consisted principally of 1) solid arrays or nests of fibroblast- and histiocyte-like cells, not infrequently containing varying amounts of intracellular hemosiderin or lipid, 2) focal areas of hemorrhage or hemorrhagic cyst-like spaces, sometimes occupying the major portion of the tumor, and 3) aggregates of chronic inflammatory cells, chiefly lymphocytes and plasmacytes, a feature that caused confusion with a lymph node metastasis in several cases. Follow-up information, available in 24 patients, revealed a variable clinical course. Twenty-one patients were alive, 11 with recurrence (including one with 9 recurrences in a 21-year period) one with recurrence and metastasis and one with metastasis. Three patients had died of metastasis 1, 3, and 13 years respectively, after the initial surgical therapy. The exact histogenesis is still obscure. Most likely it is a tumor of fibroblast- and histiocyte-like cells, akin to malignant fibrous histiocytoma, but different in its age incidence, microscopic appearance, and behavior.read more
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Association of the t(12;22)(q13;q12) EWS/ATF1 rearrangement with polyphenotypic round cell sarcoma of bone: a case report.
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Histiocytome fibreux angiomatoïde de l’enfant : 6 cas
G. Bohelay,Nicolas Kluger,Marisa Battistella,A. Biaggi-Frassati,F. Plantier,A. Harraudeau,Marie-Françoise Avril,Florence Pedeutour,Sylvie Fraitag +8 more
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PD-L1 expression in angiomatoid fibrous histiocytoma.
Joshua Byers,Hong Yin,Heather Rytting,Suzanna Logan,Mai He,Zhongxin Yu,Dehua Wang,Mikako Warren,Shamlal Mangray,Louis P. Dehner,Shengmei Zhou +10 more
TL;DR: In this article, the expression of PD-L1 was evaluated on 36 angiomatoid fibrous histiocytoma (AFH) from 36 pediatric patients by immunohistochemical staining.
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Tumoren ohne eindeutige Differenzierungsrichtung
TL;DR: The mesenchymalen Tumoren ohne eindeutige Differenzierungsrichtung umfassen eine sehr heterogene Gruppe of Neoplasien, fur die uberwiegend kein klares Konzept hinsichtlich einer Liniendifferenziersierung bzw. Differenziertung ergeben.
References
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Journal ArticleDOI
Malignant fibrous histiocytoma: an analysis of 200 cases.
TL;DR: The clinicopathologic findings in 200 cases of malignant fibrous histiocytoma (MFH) with follow‐up information are presented and it is felt it is best regarded as a primitive and pleomorphic sarcoma showing partial fibroblastic and Histiocytic differentiation, as reflected by collagen production and occasional phagocytosis.
Journal ArticleDOI
Hemangiopericytoma. An analysis of 106 cases.
Franz M. Enzinger,Bruce H. Smith +1 more
TL;DR: The close resemblance of hemangiopericytoma to richly vascular forms of fibrous histiocytomas and synovial sarcoma is emphasized, and the morphologic differences from other mesenchymal tumors showing a hemango-like vascular pattern are discussed.
Journal ArticleDOI
Histiocytic tumors (fibrous xanthoma and histiocytoma) in children.
Journal ArticleDOI
Aneurysmal Sclerosing Hemangioma of Skin
TL;DR: Although both lesions were clinically alarming, they were histologically benign and no recurrence or metastasis has developed in either case in follow-up periods of 9 and 2½ years respectively.
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