Anthraquinones in the biosynthesis of sterigmatocystin by Aspergillus versicolor.
TLDR
Experimental evidence is provided that averufin, versiconal hemiacetal acetate, and versicolorin A are biosynthetic precursors of sterigmatocystin, a xanthone.Abstract:
14C-labeled averufin, versiconal hemiacetal acetate, and versicolorin A were efficiently converted to sterigmatocystin by Aspergillus versicolor, thus providing experimental evidence that these anthraquinones are biosynthetic precursors of sterigmatocystin, a xanthone.read more
Citations
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Book ChapterDOI
New Perspectives on Aflatoxin Biosynthesis
TL;DR: The preliminary data on toxicity and mutagenicity indicate that the evolution of the aflatoxin pathway may be a response to selective pressures from mycophagous species in nature, and this system may be uniquely suited among micrcbial secondary pathways for testing this ecological hypothesis.
Genotoxicity of a Variety of Mycotoxins in the Hepatocyte Primary Culture/DMA Repair Test Using Rat and Mouse Hepatocytes1
Hideki Mori,Kiyoshi Kawai,Futoshi Ohbayashi,Tokuro Kuniyasu,Mikio Yamazaki,Takashi Hamasaki,Gary M. Williams +6 more
TL;DR: In this paper, 28 mycotoxins were studied in the hepatocyte pri mary culture/DNA repair test using rat and mouse hepatocytes and DNA repair synthesis was elicited by several compounds of unknown carcinogenicity, 5,6-dimethoxysterigmatocystin, versicolorins A and B, averufin, xanthomegnin, luteosporin, and chrysazin.
Journal ArticleDOI
Identification of averantin as an aflatoxin B1 precursor: placement in the biosynthetic pathway.
TL;DR: A new blocked mutant of Aspergillus parasiticus produces no detectable aflatoxin B1, but accumulates several polyhydroxyanthraquinones, one of which was identified as averantin, the first report of its formation by A. parasiticus.
Journal ArticleDOI
Metabolic products of microorganisms. 185. The anthraquinones of the Aspergillus glaucus group. I. Occurrence, isolation, identification and antimicrobial activity.
TL;DR: Synthetically obtained 1, 4, 6, 8-tetrahydroxy-anthraquinone was slightly more active than catenarin, whereas rubrocristin showed no antibacterial activity.
References
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High aflatoxin production on a chemically defined medium.
TL;DR: In the absence of asparagine in the medium, the toxin yields fell drastically, and the thin-layer chromatograms of the chloroform extracts of the cultures indicated the total absence of aflatoxin G(1) and the presence of new intense blue and green fluorescent bands having R(F) values lower than aflatoxins.
Journal ArticleDOI
Synthesis of versicolorin A by a mutant strain of Aspergillus parasiticus deficient in aflatoxin production
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Conversion of sterigmatocystin to aflatoxin B 1 by Aspergillus parasiticus.
TL;DR: Experimental results may indicate a biosynthetic pathway leading to aflatoxin B1 by the resting mycelium of A. parasiticus, and isolated 1-14C-Sterigmatocystin isolated from cultures of Aspergillusversicolor supplemented with (1- 14C)acetate.
Journal ArticleDOI
Step of Dichlorvos Inhibition in the Pathway of Aflatoxin Biosynthesis
TL;DR: Dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment.