Open AccessJournal Article
Anti-diabetic and antihyperlipidemic effect of allopolyherbal formulation in OGTT and STZ-induced diabetic rat model.
TLDR
The proposed hypothesis has reduced the no.Abstract:
The present study was undertaken to evaluate the antidiabetic and antihyperlipidemic activities of Allopolyherbal formulation (APHF) consisting of combinations of three well known medicinal plants used in traditional medicines (Trigonella foenum graceum, Momordica charantia, Aegle marmelos) and synthetic oral hypoglycaemic drug (Glipizide-GL). The optimized combination of lyophilized hydro-alcoholic extracts of drugs was 2:2:1 using OGTT model. The optimized PHF was simultaneously administered with GL and optimized using OGTT model in diabetic rats and further studied in STZ-induced diabetic rats for 21 days. The results (serum glucose level, lipid profile, hepatic enzymes and body weight) were compared with the standard drug GL (10 mg/kg body wt). The optimized APHF (500+5 mg/kg body wt) has shown significant antihyperglycemic and antihyperlipidemic activities. The results were comparable with the standard; even better than the GL (10 mg/kg body wt) alone. The proposed hypothesis has reduced the no. of drug components from eight to three and dose almost 50% of both PHF and GL which fulfil the FDA requirements for export. Thus the developed APHF will be an ideal alternative for the existing hypoglycemic formulations in the market with an additional advantage of hypolipidemic effect and minimizing the cardiovascular risk factors associated with diabetes.read more
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Bitter melon: a panacea for inflammation and cancer
TL;DR: The anti-oxidant, anti-inflammatory, and anti-cancer activities of Momordica charantia are summarized along with a short account of important chemical constituents, providing a basis for establishing detail biological activities of the plant and developing novel drug molecules based on the active chemical constituents.
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Evaluation of Phenolic Content Variability along with Antioxidant, Antimicrobial, and Cytotoxic Potential of Selected Traditional Medicinal Plants from India.
Garima Singh,Ajit Kumar Passsari,Vincent Vineeth Leo,Vineet Kumar Mishra,Sarathbabu Subbarayan,Bhim Singh,Brijesh Kumar,Sunil Kumar,Vijai Kumar Gupta,H. Lalhlenmawia,Senthil Kumar Nachimuthu +10 more
TL;DR: This is the first report of detection of phenolic compounds along with antimicrobial, antioxidant and cytotoxic potential of selected medicinal plants from India, which indicates that these plants might be valuable source for human and animal health.
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Phytochemical profile and pharmacological activity of Aegle marmelos Linn.
TL;DR: This review focuses on scientific evidence verifying the important pharmacological activity such as antioxidant, antidiabetic, antimicrobial, hepatoprotective, cardioprotective and anticancer activity of A. marmelos.
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In-depth pharmacological and nutritional properties of bael (Aegle marmelos): A critical review
TL;DR: The aim of the present research work is to study the ethno-botanical importance of each part of the tree, nutritional and phytochemical profiling, preservation techniques of the fruit, and medicinal actions of it.
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Moringa oleifera Lam. seed extract prevents fat diet induced oxidative stress in mice and protects liver cell-nuclei from hydroxyl radical mediated damage.
TL;DR: Moringa oleifera seed extract was found to be polyphenol rich with potent reducing power, free radicals and hydroxyl radicals scavenging activity and can be used as herbal medication against HFD induced ROS mediated disorders.
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Pharmacological actions and potential uses of Momordica charantia: a review
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TL;DR: Popularity of Momordica charantia in various systems of traditional medicine for several ailments and its efficacy in various cancers, as antibacterial as well as antiviral agent (including HIV infection), as anthelmintic and abortifacient are authenticated.
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Comparison of improved precipitation methods for quantification of high-density lipoprotein cholesterol.
TL;DR: The standard Lipid Research Clinics heparin-Mn2+ (46 mmol/L) method and five improved precipitation methods for quantification of high-density lipoprotein (HDL) cholesterol gave similar results.
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Possible regeneration of the islets of langerhans in streptozotocin diabetic rats given gymnema sylvestre leaf extracts
TL;DR: In diabetic rat pancreas, both GS3 and GS4 were able to double the islet number and beta cell number, and this herbal therapy appears to bring about blood glucose homeostasis through increased serum insulin levels provided by repair/regeneration of the endocrine Pancreas.
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Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes.
TL;DR: Findings provide further support for negative regulation of insulin action by specific PTPases in the pathogenesis of insulin resistance in human obesity, while other regulatory mechanisms may be operative in the diabetic state.