Journal ArticleDOI
Anti-theta antibodies for detecting thymus-dependent lymphocytes in the immune response of mice to SRBC.
Reads0
Chats0
TLDR
Following administration of heterologous anti-lymphocyte serum, a procedure resulting in elimination of thymus-dependent lymphocytes5,6, cells sensitive to θ antibodies disappear transiently from the lymph nodes and spleen4.Abstract:
MOUSE thymus cells possess a high concentration of the theta (θ)1 and Ly2 antigens Several approaches have demonstrated that the sensitivity of peripheral muriiie lymphocytes to the cytotoxic effect of θ and Ly antibodies is a thymus-dependent property The population of cells sensitive to the cytotoxic effect of θ antibodies disappears from lymph nodes3 and spleen4 after neonatal thymectomy Similarly, following neonatal thymectomy, the population of cells sensitive to Ly antibodies disappears from lymph nodes (unpublished results of M S and Yron) Following administration of heterologous anti-lymphocyte serum, a procedure resulting in elimination of thymus-dependent lymphocytes5,6, cells sensitive to θ antibodies disappear transiently from the lymph nodes7 and spleen4read more
Citations
More filters
Journal ArticleDOI
The Human Rosette-Forming Cell as a Marker of a Population of Thymus-Derived Cells
TL;DR: The results suggest that mu-chain determinants are present on human fetal thymocytes and blood RFC and lead to the hypothesis that human blood RFC may be chiefly thymic derived.
Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Book ChapterDOI
Membrane immunoglobulins and antigen receptors on B and T lymphocytes.
TL;DR: There are several qualitative and quantitative distinctions between T-cell and B-cell M-Ig that may explain many of the apparent differences in reactivity of these cells without requiring the existence of a different set of V genes or non-IG receptors in T cells.
Journal ArticleDOI
Specific in vitro Cytotoxicity of Thymus-derived Lymphocytes sensitized to Alloantigens
TL;DR: This study tested the effect of anti-θ serum on the cytotoxic activity of spleen cells sensitized to alloantigens, and its effect on alloantsibody-producing cells present in the same spleen cell populations was tested in parallel.
Journal ArticleDOI
The relationship between antigenic structure and the requirement for thymus-derived cells in the immune response
Marc Feldmann,Antony Basten +1 more
TL;DR: The data presented here imply that the role of T cells in humoral immunity is the presentation of antigen to B cells in such a manner as to initiate optimal antibody synthesis.
References
More filters
Journal ArticleDOI
The akr thymic antigen and its distribution in leukemias and nervous tissues
Arnold E. Reif,Joan M. Allen +1 more
TL;DR: A clear-cut serological differentiation between AKR lymphocytes of thymic and non-thymic origin is reported: these two cell types are antigenically distinct.
Journal ArticleDOI
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.
TL;DR: The results were considered to support the concept that memory resides in the T cell population and that collaboration between T and B cells is necessary for an optimal secondary antibody response.
Journal ArticleDOI
Cell to cell interaction in the immune response : i. hemolysin-forming cells in neonatally thymectomized mice reconstituted with thymus or thoracic duct lymphocytes
TL;DR: It is concluded that thoracic duct lymph contains a mixture of cell types: some are hemolysin-forming cell precursors and others are antigen-reactive cells which can interact with antigen and initiate the differentiation of hemoly sin-forming Cell precursor to antibody-forming cells.
Journal ArticleDOI
Theta isoantigen as a marker of thymus-derived lymphocytes in mice.
TL;DR: In this paper, the theta (θ) isoantigen is determined by a single locus with two alleles: θAKR and RF mice and θC3H present in most other inbred strains of mice tested, which is found chiefly in thymus lymphocytes and brain, and to a lesser extent in peripheral lymphocytes in mice.
Journal Article
Theta isoantigen as a marker of thymus-derived lymphocytes in mice (Reprinted from Nature vol 224, pg 378-379, 1969)
TL;DR: To establish that θ is a marker that will differentiate one type of lymphocyte from another, it is necessary to demonstrate that there is a discrete population of peripheral lymphocytes which carry the antigen and that these cells are thymus-dependent.
Related Papers (5)
The akr thymic antigen and its distribution in leukemias and nervous tissues
Arnold E. Reif,Joan M. Allen +1 more