Journal ArticleDOI
Antibacterial activity of flavanone isolated from Sophora exigua against methicillin‐resistant Staphylococcus aureus and its combination with antibiotics
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TLDR
The proposed flavanone would be a potent phytotherapeutic agent against MRSA infections, based on bactericidal action and synergistic effects with anti‐MRSA antibiotics.Abstract:
5,7,2',4'-Tetrahydroxy-8-lavandulyl-flavanone, isolated from Sophora exigua, completely inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus (MRSA) at concentrations of 3.13-6.25 μg/mL. The anti-MRSA effect was based on bactericidal action. In combinations of the flavanone with vancomycin, minocycline and rifampicin, the fractional inhibitory concentration indices were 0.90, 0.88 and 0.85, respectively, indicating partial synergistic effects with anti-MRSA antibiotics. The proposed flavanone would be a potent phytotherapeutic agent against MRSA infections.read more
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Antimicrobial activity of flavonoids
T.P. Tim Cushnie,Andrew J. Lamb +1 more
TL;DR: Several high-quality investigations have examined the relationship between flavonoid structure and antibacterial activity and these are in close agreement, and future studies may allow the development of a pharmacologically acceptable antimicrobial agent or class of agents.
Journal ArticleDOI
Comparative study on the antibacterial activity of phytochemical flavanones against methicillin-resistant Staphylococcus aureus
Hironori Tsuchiya,Masaru Sato,Takashi Miyazaki,Shuu Fujiwara,Shingo Tanigaki,Masayoshi Ohyama,Toshiyuki Tanaka,Munekazu Iinuma +7 more
TL;DR: In this paper, the minimum inhibitory concentrations (MICs) of phytochemical flavanones to clinical isolates of MRSA were determined by a serial agar dilution method.
Comparative Study on the Antibacterial Activity of Phytochemical Flavanones against Methicillin-resistant Staphylococcus aureus.
Tsuchiya,Hironori,Sato,Masaru,Miyazaki,Takashi,Fujiwara,Shuu,Tanigaki,Shingo,Ohyama,Masayoshi,Tanaka,Toshiyuki,Iinuma,Munekazu +15 more
TL;DR: Tetrahydroxyflavanones with these structural characteristics isolated from Sophora exigua and Echinosophora koreensis showed intensive activity to inhibit the growth of all MRSA strains at 3.13-6.25 micrograms/ml.
Journal ArticleDOI
Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai
TL;DR: The results support the use of prenylated flavonoids in Asian traditional medicine to treat microbial infection and indicate a high potential for prenylonoids as antimicrobial agents as well as anti-inflammatory agents.
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Adjunctive use of rifampin for the treatment of Staphylococcus aureus infections: a systematic review of the literature
TL;DR: In vitro results of interactions between rifampin and other antibiotics are method dependent and often do not correlate with in vivo findings, while adjunctive therapy seems most promising for the treatment of osteomyelitis and prosthetic device-related infections.
References
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Methicillin-Resistant Staphylococcus aureus
TL;DR: In the early 1940s the introduction of benzylpenicillin (Penicillin G) temporarily solved the problem of staphylococcal infections, but the continued use of this agent caused the selection of resistant strains, which produced penicillinase (β-lactamase).
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Methicillin-resistant Staphylococcus aureus: A consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management
Maury Ellis Mulligan,Katherine A. Murray-Leisure,Bruce S. Ribner,Harold C. Standiford,Joseph F. John,Joyce A. Korvick,Carol A. Kauffman,Victor L. Yu +7 more
TL;DR: Indications for antibiotic therapy for eradication of colonization and treatment of infection are reviewed, and recommendations for handling an outbreak, surveillance, and culturing of patients are presented based on the known epidemiology.
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Emergence of Vancomycin Resistance in Coagulase-Negative Staphylococci
TL;DR: It is shown that coagulase-negative staphylococci are the most common agents responsible for peritonitis in patients undergoing continuous ambulatory peritoneal dialysi and that vancomycin has beco e the resistance of methicilli.
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Staphylococcus aureus endocarditis. Combined therapy with vancomycin and rifampin.
Ralph J. Faville,Darwin E. Zaske,Edward L. Kaplan,Kent B. Crossley,Leon D. Sabath,Paul G. Quie +5 more
TL;DR: Two children with persistent bacteremia and endocarditis due to Staphylococcus aureus failed to respond to vancomycin therapy, even though serum levels greatly exceeded the inhibitory concentrations.
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Vancomycin ototoxicity and nephrotoxicity. A review
George R. Bailie,Deborah Neal +1 more
TL;DR: Efforts should be made to tailor individual patient’s regimens to produce peak and trough serum vancomycin concentrations to within the widely accepted ranges of 30 to 40 and 5 to 10 mg/L, respectively, and the concomitant use of other potentially nephrotoxic and ototoxic agents should be avoided.