Journal ArticleDOI
Antibacterial calcium phosphate composite cements reinforced with silver-doped magnesium phosphate (newberyite) micro-platelets
Reads0
Chats0
TLDR
The effort to enhance CPC's poor mechanical properties with micro-platelet reinforcement and impart antibacterial functionalities in composites with the aim to inhibit surgical site infections (SSI) was successful.Abstract:
This article demonstrates our efforts in developing and evaluating all-ceramic, biodegradable composites of calcium phosphate cements (CPCs) reinforced with silver (Ag)-doped magnesium phosphate (MgP) crystals Two primary goals of this study were to 1) enhance CPC's poor mechanical properties with micro-platelet reinforcement, and 2) impart antibacterial functionalities in composites with the aim to inhibit surgical site infections (SSI) The work embodies three novel features First, as opposed to well-known reinforcements with whisker or fiber-like morphology, we explored micro-platelets for the first time as the strengthening phase in the CPC matrix Second, in contrast to conventional polymeric or calcium phosphate (CaP) fibrous reinforcements, newberyite (NB, MgHPO43H2O) micro-platelets belonging to the less explored yet promising MgP family, were evaluated as reinforcements for the first time Third, NB micro-platelets were doped with Ag+ ions (AgNB, Ag content: 2 wt%) for enhancing antibacterial functionalities Results indicated that 1 wt% of AgNB micro-platelet incorporation in the CPC matrix enhanced the compressive and flexural strengths by 200% and 140% respectively as compared to the un-reinforced ones Besides, antibacterial assays revealed effective bactericidal functionalities (>99% bacteria kill) of the AgNB reinforced CPCs against Escherichia coli Finally, cytocompatibility studies confirmed favorable pre-osteoblast cell proliferation and differentiation in vitro Hence, this effort was successful in developing a self-setting and injectable AgNB reinforced CPC composition with favorable mechanical and antibacterial propertiesread more
Citations
More filters
High strength resorbable brushite bone cement with controlled drug releasing capabilities
TL;DR: In this paper, the authors investigated whether near elimination of porosity would prevent a burst release profile of incorporated antibiotics that is common to prior calcium phosphate cement delivery matrices, and found that up to 2 wt.% of vancomycin and ciprofloxacin could be incorporated into the cement system without loss of wet compressive strength.
Journal Article
Mechanical Properties and Antibiotic Release Characteristics of Poly(methyl methacrylate)-based Bone Cement Formulated with Mesoporous Silica Nanoparticles
TL;DR: The combination of excellent mechanical properties and sustainable drug delivery efficiency demonstrates the potential applicability of MSN-functionalized PMMA bone cements for orthopedic surgery to prevent post-surgery infection.
Journal ArticleDOI
Monetite, An important Calcium Phosphate Compound - Its Synthesis, Properties and Applications in Orthopedics.
TL;DR: In this paper, a review of the potential of monetite for hard tissue repair and regeneration is presented, focusing on the in vitro and in vivo properties of the material and highlighting its potential as an orthopedic material of choice.
Journal ArticleDOI
Antibacterial Honeycomb Scaffolds for Achieving Infection Prevention and Bone Regeneration
TL;DR: In this paper , the authors fabricated antibacterial honeycomb scaffolds by replacing carbonate apatite with silver phosphate locally on the scaffold surface via dissolution-precipitation reactions.
Journal ArticleDOI
Biodegradable magnesium phosphates in biomedical applications.
TL;DR: This review focuses on the state-of-the-art progress made in magnesium phosphate-based biomaterials and their biomedical applications, including nanostructured magnesium phosphates and magnesiumosphates-based cements, ceramics, scaffolds, coatings and so on.
References
More filters
Journal ArticleDOI
A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment
TL;DR: A review of the antibacterial effects of silver nanomaterials, including proposed antibacterial mechanisms and possible toxicity to higher organisms, is presented in this paper, where the authors suggest that further research is warranted given the already widespread and rapidly growing use of silver nanoparticles.
Journal ArticleDOI
Silver Colloid Nanoparticles: Synthesis, Characterization, and Their Antibacterial Activity
Aleš Panáček,Libor Kvítek,Robert Prucek,Milan Kolar,Renata Vecerova,N. Pizúrová,Virender K. Sharma,Tat’jana Nevečná,Radek Zboril +8 more
TL;DR: The reduction of [Ag(NH(3))(2)](+) by maltose produced silver particles with a narrow size distribution with an average size of 25 nm, which showed high antimicrobial and bactericidal activity against Gram-positive and Gram-negative bacteria, including highly multiresistant strains such as methicillin-resistant Staphylococcus aureus.
Journal ArticleDOI
Antibacterial Activity and Mechanism of Action of the Silver Ion in Staphylococcus aureus and Escherichia coli
TL;DR: The results of the present study suggest that silver ions may cause S. aureus and E. coli bacteria to reach an ABNC state and eventually die.
Journal ArticleDOI
Crack deflection processes—I. Theory
TL;DR: In this article, a fracture mechanics approach has been used to predict fracture toughness increases due to crack deflection around second phase particles, based on a determination of the initial tilt and the maximum twist of the crack front between particles.
Journal ArticleDOI
A review of the biomaterials technologies for infection-resistant surfaces.
TL;DR: Among the new strategies, the use of phages or of antisense peptide nucleic acids are discussed, as well as the possibility to modulate the local immune response by active cytokines, to contrast the establishment of an implant infection.