Antibodies to the β-amyloid peptide cross-react with conformational epitopes in human fibrinogen subunits from peripheral blood
TLDR
Antibodies to the Alzheimer disease β‐amyloid peptide were used to identify βAP precursor fragments in blood and these data are significant for efforts to develop immunochemical assays to diagnose and monitor the progression of AD.About:
This article is published in FEBS Letters.The article was published on 1990-05-07 and is currently open access. It has received 39 citations till now. The article focuses on the topics: Epitope & Fibrinogen.read more
Citations
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Plasma and cerebrospinal fluid Levels of amyloid β proteins 1-40 and 1-42 in Alzheimer disease
Pankaj Mehta,Tuula Pirttilä,Sangita P. Mehta,Eugene A. Sersen,Paul S. Aisen,Henryk M. Wisniewski +5 more
TL;DR: M measurement of plasma Abeta40 levels is not useful to support the clinical diagnosis of AD, and lower levels of CSF Abeta42 in the AD group are consistent with previous studies.
Patent
Prevention and treatment of amyloidogenic disease
TL;DR: In this article, the authors provide compositions and methods for treatment of amyloidogenic diseases, such as Alzheimer's disease, which entail administering an agent that induces a beneficial immune response against an Amyloid deposit in the patient.
Patent
Humanized antibodies that recognize beta amyloid peptide
Guriq Basi,Jose William Saldanha +1 more
TL;DR: In this article, the authors presented improved agents and methods for treatment of diseases associated with amyloid deposits of Aβ in the brain of a patient, including humanized antibodies.
Journal ArticleDOI
Amyloid β protein in plasma from patients with sporadic Alzheimer's disease
Akira Tamaoka,Tetsuo Fukushima,Naoya Sawamura,K. Ishikawa,Eiichi Oguni,Yasuko Komatsuzaki,Shin'ichi Shoji +6 more
TL;DR: The unlikelihood that plasma Aβ assays would be useful as a diagnostic tool for Alzheimer's disease is suggested.
Journal Article
Astrocytes containing amyloid beta-protein (Abeta)-positive granules are associated with Abeta40-positive diffuse plaques in the aged human brain.
Hiromasa Funato,M Yoshimura,Tsuneo Yamazaki,Takaomi C. Saido,Y. Ito,Junko Yokofujita,Riki Okeda,Yasuo Ihara +7 more
TL;DR: Immunoelectron microscopy revealed that nonfibrillar Abeta immunoreactivity was located within lipofuscin-like granules in somewhat swollen astrocytes, raising the possibility that astroCytes take up Abeta and attempt to degrade it in lysosomes in the aged brain.
References
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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
George G. Glenner,Caine W. Wong +1 more
TL;DR: A purified protein derived from the twisted beta-pleated sheet fibrils in cerebrovascular amyloidosis associated with Alzheimer's disease has been isolated and Amino acid sequence analysis and a computer search reveals this protein to have no homology with any protein sequenced thus far.
Journal ArticleDOI
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
Journal ArticleDOI
Amyloid plaque core protein in Alzheimer disease and Down syndrome
Colin L. Masters,Gail Simms,Nicola A. Weinman,Gerd Multhaup,Brian L. McDonald,Konrad Beyreuther +5 more
TL;DR: The shared 4-kDa subunit indicates a common origin for the amyloids of the plaque core and of the congophilic angiopathy of Alzheimer disease and Down syndrome.
Journal ArticleDOI
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity
TL;DR: It is suggested that protease inhibition by the longer APP(s) could be related to aberrant APP catabolism, and a cDNA library of a human glioblastoma cell line is isolated, together with a new cDNA which contains a 225-nucleotide insert.
Journal ArticleDOI
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease.
Rudolph E. Tanzi,Andrea I. McClatchey,Edward D. Lamperti,Edward D. Lamperti,Edward D. Lamperti,Lydia Villa-Komaroff,Lydia Villa-Komaroff,James F. Gusella,Rachael L. Neve,Rachael L. Neve +9 more
TL;DR: In this paper, the authors used complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and identified a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor.
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Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
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