Edward D. Lamperti

TL;DR: The results demonstrate that Tet2 is important for normal myelopoiesis, and suggest that disruption of TET2 enzymatic activity favours myeloid tumorigenesis, which may prove valuable as a diagnostic and prognostic tool to tailor therapies and assess responses to anticancer drugs.

TL;DR: In this paper, the authors used complementary DNA libraries constructed from peripheral tissues to determine whether the messenger RNA encoding APP in these tissues is identical to that expressed in brain, and identified a second APP mRNA that encodes an additional internal domain with a sequence characteristic of a Kunitz-type serine protease inhibitor.

TL;DR: It is demonstrated that the transcription factor NFAT controls the program of T cell exhaustion and promotes T cell anergy and exhaustion by binding at sites that do not require cooperation with AP-1.

TL;DR: It is shown that Tet2 is a critical regulator of self-renewal and differentiation of hematopoietic stem cells (HSCs) and has a critical role in regulating the expansion and function of HSCs, presumably by controlling 5hmC levels at genes important for the self-Renewal, proliferation, and differentiation.

TL;DR: The A2BAR is identified as a new critical regulator of inflammation and vascular adhesion primarily via signals from hematopoietic cells to the vasculature, focusing attention on the receptor as a therapeutic target.