Journal ArticleDOI
Antileukemic Principles Isolated from Euphorbiaceae Plants
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TLDR
Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice.Abstract:
Extracts of Euphorbia esula L. and Croton tiglium L., two members of the Euphorbiaceae which have been used widely in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice. Systematic fractionation of the extract of Euphorbia esula L. led to characterization of a major antileukemic component as the new diterpenoid diester, ingenol 3,20-dibenzoate. Similar fractionation of Croton oil led to characterization of phorbol 12-tiglate 13-decanoate as an active principle.read more
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Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis
TL;DR: This review aims at highlighting photochemical transformations as a tool for rapidly accessing structurally and stereochemically diverse scaffolds for complex polycyclic carbon skeletons with impressive efficiency, which are of high value in total synthesis.
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Active principle from Moringa oleifera Lam leaves effective against two leukemias and a hepatocarcinoma
Mutasim M. Khalafalla,Eltayb Abdellatef,Hussain Mohammed Dafalla,Amr Nassrallah,Khalid M. Aboul-Enein,David A. Lightfoot,Fadl E. El-Deeb,Hany A. El-Shemy +7 more
TL;DR: Different extracts from the leaves of Moringa or drumstick tree are tested for activity against leukemia and hepatocarcinoma cells in vitro and it is found that M. oleifera may have potential for use as source of natural treatment for diseases such as cancer.
Journal ArticleDOI
Action of phorbol esters in cell culture: mimicry of transformation, altered differentiation, and effects on cell membranes.
TL;DR: A model of "two stage" carcinogenesis encompassing the known molecular and cellular effects of initiating carcinogens and tumor promoters is presented and indicates that transformation mimetic and differentiation effects are exerted by plant diterpenes that have tumor-promoting activity but not by congeners that lack such activity.
Journal ArticleDOI
Cytotoxic activity of Brazilian Cerrado plants used in traditional medicine against cancer cell lines
Mariana Laundry de Mesquita,José Elias de Paula,Cláudia Pessoa,Manoel Odorico de Moraes,Letícia V. Costa-Lotufo,Raphaël Grougnet,Sylvie Michel,Francois Tillequin,Laila S. Espindola +8 more
TL;DR: To investigate the cytotoxic potential of 412 extracts from Brazilian Cerrado plants used in traditional medicine belonging to 21 families against tumor cell lines in culture,Bioassay-guided fractionation of the last extract led to the isolation of glaucarubinone, which showed pronounced activity against the four cell lines studied.
Journal ArticleDOI
Screening of Higher Plants Reputed as Pesticides Using the Brine Shrimp Lethality Assay
TL;DR: Five plants reputed to have pesticidal properties were extracted and screened using the brine shrimp lethality bioassay and an additional five medicinal plants were also extracted AND screened.
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Protocols for screening chemical agents and natural products against animal tumors and other biological systems
Journal ArticleDOI
Mezerein: antileukemic principle isolated from Daphne mezereum L
S. M. Kupchan,RL Baxter +1 more
TL;DR: An alcohol-water extract of Daphne mezereum L., a plant widely used in folk medicine for treating cancers, showed antileukemic activity against the P-388 lymphocytic leukemia in mice.
Journal ArticleDOI
Letter: Gnididin, gniditrin, and gnidicin, novel potent antileukemic diterpenoid esters from Gnidia lamprantha.
S. Morris Kupchan,James G. Sweeny,Robert L. Baxter,Tatsushi Murae,Virginia A. Zimmerly,Barry R. Sickles +5 more