Journal ArticleDOI
Antiproliferative effects of isopentenylated coumarins isolated from Phellolophium madagascariense Baker.
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TLDR
The anticancer activity of the three isolated compounds and of a synthetic sample of osthol was evaluated on L1210 mouse leukemia and on human prostatic cancer hormonosensitive LNCaP and hormonoindependent PC3 and DU145 cell lines.About:
This article is published in Natural Product Research.The article was published on 2006-08-21. It has received 38 citations till now. The article focuses on the topics: Osthol.read more
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Journal ArticleDOI
Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine.
TL;DR: The pharmacological properties of osthole are summarized and an overview of the underlying mechanisms are given, which showcase its potential as a multitarget alternative medicine.
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Osthole induces G2/M arrest and apoptosis in lung cancer A549 cells by modulating PI3K/Akt pathway.
TL;DR: Osthole inhibited the growth of human lung cancer A549 cells by inducing G2/M arrest and apoptosis and may have a therapeutic application in the treatment of human Lung cancer.
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Growth Inhibition and Apoptosis Induced by Osthole, A Natural Coumarin, in Hepatocellular Carcinoma
Lurong Zhang,Guorong Jiang,Fei Yao,Yan He,Guoqiang Liang,Yinsheng Zhang,Bo Hu,Yan Wu,Yunsen Li,Haiyan Liu +9 more
TL;DR: Osthole could significantly inhibit HCC growth in vitro and in vivo through cell cycle arrest and inducing apoptosis by suppressing NF-κB activity and promoting the expressions of apoptosis-related genes.
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Pharmacological and Nutritional Effects of Natural Coumarins and Their Structure-Activity Relationships
Jing-Jing Zhu,Jian-Guo Jiang +1 more
TL;DR: Coumarin molecules can be customized by the target site to prevent systemic side effects by virtue of structural modification, and the specific site on the core structure of coumarin exhibits one or more activities due to the electronic or steric effects of the substituents.
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Effects of Osthole on Migration and Invasion in Breast Cancer Cells
TL;DR: It is found that Osthole is effective in inhibiting the migration and invasion of breast cancer cells by wound healing and transwellAssays and indicates a need for further evaluation of Osthole in breast cancer chemotherapy and chemoprevention.
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Journal ArticleDOI
Coumarins and bicoumarin from Ferula sumbul: anti-HIV activity and inhibition of cytokine release.
Ping Zhou,Yoshihisa Takaishi,Hong-Quan Duan,Bei Chen,Gisho Honda,Michiho Itoh,Yoshio Takeda,Olimjon K. Kodzhimatov,Kuo Hsing Lee +8 more
TL;DR: The methanol extract of the dried roots of Ferula sumbul afforded two furanocoumarin esters and some of the isolated compounds showed anti-HIV activity and very weak inhibition of cytokine release.
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5-Lipoxygenase and Cyclooxygenase-1 Inhibitory Active Compounds from Atractylodes lancea
TL;DR: Bioactivity-guided fractionation of the n-hexane extract led to the isolation of a new compound atractylochromene (1), a potent inhibitor in both test systems and the sesquiterpene atractylon and the coumarin osthol turned out to be moderate but selective 5-lipoxygenase inhibitors.
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Inhibitory effects of Angelica pubescens f. biserrata on 5-lipoxygenase and cyclooxygenase.
TL;DR: Linoleic acid, osthol, osthenol and two polyacetylenes, falcarindiol and 11(S),16(R)-dihydroxyoctadeca-9Z,17-diene-12,14-diyn-1-yl acetate were found to be the most active compounds responsible for the inhibitory activity of the dichloromethane extract of the roots of Angelica pubescens f.
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Medicinal plants of the eastern region of Madagascar
TL;DR: Sixty-eight plants used in the traditional medicinal practices of the Betsimisaraka and Tanala peoples of the eastern region of Madagascar are reported and new preparations and utilizations were based on the ethnobotanical data collected.