Journal ArticleDOI
Arteriosclerosis Obliterans and Associated Risk Factors in Insulin-dependent and Non-insulin-dependent Diabetes
K. W. Beach,D. E. Strandness +1 more
Reads0
Chats0
TLDR
The prevalence of arteriosclerosis obliterans of the legs was determined by a battery of noninvasive tests in 141 insulin-dependent and 289 non-insulin-dependent diabetic subjects and in 64 other subjects, finding no consistently significant correlations with fasting glucose, glycosylated hemoglobin, or obesity.Abstract:
SUMMARY The prevalence of arteriosclerosis obliterans (ASO) of the legs was determined by a battery of noninvasive tests in 141 insulin-dependent and 289 non-insulin-dependent diabetic subjects and in 64 other subjects. The prevalence of detectable ASO ranges from 18% in the younger IDDM group to 41% in the diet-treated NIDDM group. The prevalence of ASO increases 7.5% per decade, appears to increase 6.5% in the age-adjusted IDDM group, 9% in males, 19% in those with hypertension, and 12% in smokers. No consistently significant correlations with fasting glucose, glycosylated hemoglobin, or obesity were found. After accounting for the effect of smoking, the increased risk for ASO in males becomes nonsignificant.read more
Citations
More filters
Journal ArticleDOI
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
TL;DR: In this article, the authors found that abnormalities of endothelial function are also present in patients with insulin-dependent diabetes mellitus and may contribute to the pathogenesis of vascular disease in these individuals.
Journal ArticleDOI
Diabetes and atherosclerosis: an epidemiologic view.
TL;DR: Only a relatively small proportion of the excessive occurrence of ASVD in diabetics can be explained by the effects of diabetes on the levels of general risk factors for ASVD, but the major proportion remains unexplained and must be due to effects of Diabetes itself through mechanisms that are incompletely understood.
Journal ArticleDOI
Relationship of High and Low Ankle Brachial Index to All-Cause and Cardiovascular Disease Mortality The Strong Heart Study
Helaine E. Resnick,Robert S. Lindsay,Mary M. McDermott,Richard B. Devereux,Kristina L. Jones,Richard R. Fabsitz,Barbara V. Howard +6 more
TL;DR: The data suggest that the upper limit of normal ABI should not exceed 1.40, highlighting a U-shaped association between this noninvasive measure of peripheral arterial disease and mortality risk.
Journal ArticleDOI
Diagnosis and Treatment of Chronic Arterial Insufficiency of the Lower Extremities: A Critical Review
Jeffrey I. Weitz,J. Byrne,Clagett Gp,Michael E. Farkouh,J. M. Porter,David L. Sackett,Strandness De,Lloyd M. Taylor +7 more
TL;DR: Atherosclerosis is the most common cause of chronic arterial occlusive disease of the lower extremities and symptoms of intermittent claudication should be viewed as a sign of systemic atherosclerosis.
Journal ArticleDOI
Lower-Extremity Amputation in People With Diabetes: Epidemiology and Prevention
Diane E. Bild,Joseph V. Selby,Pomeroy Sinnock,Warren S. Browner,Paula Braveman,Jonathon A Showstack +5 more
TL;DR: Programs to reduce amputations among people with diabetes in primarycare settings should identify those at high risk; clinically evaluate individuals to determine specific risk status; ensure appropriate preventive therapy, treatment for foot problems, and follow-up; and, when necessary, refer patients to specialists.
References
More filters
Journal ArticleDOI
Combined clinical and pathologic study of diabetic and nondiabetic peripheral arterial disease.
TL;DR: The results of a combined clinical and pathologic study of large and small arteries in ihe diabetic and nondiabetic patient show that the diabetic has the same incidence of occlusion in the femoral-popliteal system but a higher incidence below the knee.
Journal ArticleDOI
Effects of hypoglycemic agents on vascular complications in patients with adult-onset diabetes. 3. Clinical implications of UGDP results.
TL;DR: The hypothesis that control of the blood glucose level prevents or delays the vascular complications of diabetes has been supported so far only by evidence which is largely conjectural.
Journal ArticleDOI
The Relationship of Cardiovascular Disease to Hyperglycemia
TL;DR: The high prevalence of vascular disease among diabetics has long been recognized and has become increasingly important since the acute complications of diabetes, acidosis, and infection hav...
Journal ArticleDOI
Response of ankle systolic pressure to leg exercise in mild or questionable arterial disease.
TL;DR: In 37 normal limbs ankle pressure after exercise either remained above or fell only a few millimeters of mercury below the brachial systolic pressure, thus useful in the assessment of patients with mild or questionable arterial disease.