Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population.
Neetha N Vijayan,Sujatha Bhaskaran,Linda V. Koshy,Chandrasekhar Natarajan,Lekshmy Srinivas,Chandrasekharan M. Nair,Priya M Allencherry,Moinak Banerjee +7 more
TLDR
The present study suggests that in addition to ethnic bias, socio-cultural factors should be considered while evaluating genotype phenotype correlations, in association and treatment response to complex disorders like schizophrenia.Abstract:
Alterations in the dopamine transmission and receptor density are hypothesized in the pathophysiology of schizophrenia but ethnic disparities are reported to exist in disease association and therapeutic response to psychotropic medication. Antipsychotics have higher binding affinity to D2 subtype of dopamine receptor. DRD2 Cys311, TaqIB1 and TaqIA1 variants are considered to have either reduced affinity for dopamine and hypo-dopaminergic activity. We examined the role of Taq1B, Taq1D, S311C, H313H and Taq1A polymorphisms of DRD2 gene in schizophrenia and antipsychotic treatment response in 213 patients and 196 controls from a homogenous South Indian population. A more detailed genotype phenotype association analysis was carried out to understand the disease in terms of its socio-cultural factors. H313HTT genotype was found to be associated with schizophrenia (P = 0.004) while TaqIB1B1 genotype was significantly associated with higher psychopathology score. When treatment response was considered H313HCC, TaqIA2A2 and Taq1D1D1 had higher mean improvement scores. TaqID1D1 and H313HTT genotype were found to be significantly higher in responders than in nonresponder group. Distinct shift in the LD patterns of responder and non-responder group was observed. Certain symptoms were characteristic of our patient population. Following medication the scores and presentation of these symptoms tend to vary in the responder and non-responder groups. Based on genotype phenotype correlations it can be suggested that certain polymorphisms can be defined for their critical functions in disease and their role in treatment response in South Indian population. The present study suggests that in addition to ethnic bias, socio-cultural factors should also be considered while evaluating genotype phenotype correlations, in association and treatment response to complex disorders like schizophrenia.read more
Citations
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D2 Receptor Genetic Variation and Clinical Response to Antipsychotic Drug Treatment: A Meta-Analysis
TL;DR: The authors conducted the first meta-analysis to examine the relationship between DRD2 polymorphisms and antipsychotic drug response in schizophrenia patients, finding that variation in the DRD(2) gene is associated with clinical response to antipsychotics.
Journal ArticleDOI
Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction
Jian-Ping Zhang,Anil K. Malhotra +1 more
TL;DR: This article reviews the pharmacogenetic literature from early 1990s to 2010, focusing on two aspects of drug action: pharmacokinetics and pharmacodynamics.
Journal ArticleDOI
Pharmacogenetics of response to antipsychotics in patients with schizophrenia.
TL;DR: Pharmacogenetic studies support the role of cytochrome P450 enzymes and dopamine receptor variants in the development of antipsychotic-induced movement disorders, with a contribution of serotonergic receptors and other gene variants implicated in the mechanism of action of antippsychotics.
Journal ArticleDOI
The ANKK1 kinase gene and psychiatric disorders.
Guillermo Ponce,Rocío Pérez-González,M. Aragues,Tomás Palomo,R. Rodriguez-Jimenez,Miguel Ángel Jiménez-Arriero,Janet Hoenicka +6 more
TL;DR: Current data show that the TaqIA polymorphism may be a marker of both DRD2 and ANKK1 genetic variants, which raises the question of whether signaling players intervene in the pathophysiology of psychiatric disorders.
Journal ArticleDOI
Genetic susceptibility to schizophrenia: role of dopaminergic pathway gene polymorphisms.
Meenal Gupta,Chitra Chauhan,Pallav Bhatnagar,Simone Gupta,Sandeep Grover,Prashant Singh,Meera Purushottam,Odity Mukherjee,Sanjeev Jain,Samir K. Brahmachari,Ritushree Kukreti +10 more
TL;DR: The present study emphasizes the need for multigene interaction studies in complex disorders such as schizophrenia and to understand response to drug treatment, which could lead to a targeted and more effective treatment.
References
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TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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TL;DR: Haploview is a software package that provides computation of linkage disequilibrium statistics and population haplotype patterns from primary genotype data in a visually appealing and interactive interface.