R
Reiji Yoshimura
Researcher at University of Occupational and Environmental Health Japan
Publications - 314
Citations - 5634
Reiji Yoshimura is an academic researcher from University of Occupational and Environmental Health Japan. The author has contributed to research in topics: Major depressive disorder & Medicine. The author has an hindex of 36, co-authored 269 publications receiving 4822 citations.
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Journal ArticleDOI
Abnormal asymmetries in subcortical brain volume in schizophrenia.
Naohiro Okada,Masaki Fukunaga,Fumio Yamashita,Daisuke Koshiyama,Hidenaga Yamamori,Kazutaka Ohi,Yuka Yasuda,Michiko Fujimoto,Yoshifumi Watanabe,Noriaki Yahata,Noriaki Yahata,Kiyotaka Nemoto,Derrek P. Hibar,T.G.M. van Erp,Haruo Fujino,Masanori Isobe,Shuichi Isomura,Tatsunobu Natsubori,Hisashi Narita,Naoki Hashimoto,Jun Miyata,Shinsuke Koike,Tsutomu Takahashi,Hidenori Yamasue,Koji Matsuo,Toshiaki Onitsuka,Tetsuya Iidaka,Yasuhiro Kawasaki,Reiji Yoshimura,Michio Suzuki,Jessica A. Turner,Masatoshi Takeda,Paul M. Thompson,Norio Ozaki,Kiyoto Kasai,Ryota Hashimoto +35 more
TL;DR: The findings suggest the possibility of aberrant laterality in neural pathways and connectivity patterns related to the pallidum in schizophrenia, and replicate the rank order of effect sizes for subcortical volumetric changes in schizophrenia reported by the ENIGMA consortium.
Journal ArticleDOI
Effects of paroxetine or milnacipran on serum brain-derived neurotrophic factor in depressed patients.
Reiji Yoshimura,Masae Mitoma,Atsuko Sugita,Hikaru Hori,Tatsuya Okamoto,Wakako Umene,Nobuhisa Ueda,Jun Nakamura +7 more
TL;DR: Serum BDNF levels in responders were significantly increased 2.6- and 1.8-fold 8 weeks after treatment with paroxetine or milnacipran, respectively, suggesting that both drugs improve the depressive state by increasingBDNF levels.
Journal ArticleDOI
Higher plasma interleukin-6 (IL-6) level is associated with SSRI- or SNRI-refractory depression
Reiji Yoshimura,Hikaru Hori,Atsuko Ikenouchi-Sugita,Wakako Umene-Nakano,Nobuhisa Ueda,Jun Nakamura +5 more
TL;DR: It is suggested that higher plasma IL-6 activity is associated with the refractoriness of depression, and plasmaIL-6 levels might be a predictor for response to SSRIs or SNRI.
Journal ArticleDOI
A genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder
Masashi Ikeda,Atsushi Takahashi,Yoichiro Kamatani,Yuko Okahisa,Hiroshi Kunugi,Norio Mori,Tsukasa Sasaki,Tetsuro Ohmori,Yasumasa Okamoto,Hiroaki Kawasaki,Shinji Shimodera,Tadafumi Kato,Hiroshi Yoneda,Reiji Yoshimura,Masaomi Iyo,Koichi Matsuda,Masato Akiyama,Kyota Ashikawa,Kouichi Kashiwase,Katsushi Tokunaga,Kenji Kondo,Takeo Saito,Ayu Shimasaki,Kohei Kawase,Tsuyoshi Kitajima,Koji Matsuo,Masanari Itokawa,Toshiyuki Someya,Toshiya Inada,Ryota Hashimoto,Takeshi Inoue,Kazufumi Akiyama,Hisashi Tanii,Heii Arai,Shigenobu Kanba,Norio Ozaki,Ichiro Kusumi,Takeo Yoshikawa,Michiaki Kubo,Nakao Iwata +39 more
TL;DR: Two novel and three previously implicated loci are significantly associated with bipolar disorder and that the BD ‘risk’ effect are shared between Japanese and European populations are indicated.
Journal ArticleDOI
Brain-Derived Neurotrophic Factor and Major Depressive Disorder: Evidence from Meta-Analyses.
TL;DR: BDNF is best understood to be a biomarker for the state of MDD and its treatment response rather than a risk factor for MDD.