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Open AccessJournal ArticleDOI

Avalanches in the lung: A statistical mechanical model.

TLDR
It is found that the treelike structure of the airways, together with the simplest assumptions concerning opening threshold pressures of each airway, is sufficient to explain the existence of power-law distributions observed experimentally.
Abstract
We study a statistical mechanical model for the dynamics of lung inflation which incorporates recent experimental observations on the opening of individual airways by a cascade or avalanche mechanism. Using an exact mapping of the avalanche problem onto percolation on a Cayley tree, we analytically derive the exponents describing the size distribution of the first avalanches and test the analytical solution by numerical simulations. We find that the treelike structure of the airways, together with the simplest assumptions concerning opening threshold pressures of each airway, is sufficient to explain the existence of power-law distributions observed experimentally.

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Journal ArticleDOI

Self-organized criticality

TL;DR: In this paper, the authors introduced the concept of self-organized criticality to explain the behavior of the sandpile model, where particles are randomly dropped onto a square grid of boxes and when a box accumulates four particles they are redistributed to the four adjacent boxes or lost off the edge of the grid.
Journal ArticleDOI

Respiratory Fluid Mechanics and Transport Processes

TL;DR: The subject areas covered include nasal flow and transport,Airway gas flow, alternative modes of ventilation, nonrespiratory gas transport, aerosol transport, airway stability, mucus transport, pulmonary acoustics, surfactant dynamics and delivery, and pleural liquid flow.
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Complexity of chronic asthma and chronic obstructive pulmonary disease: implications for risk assessment, and disease progression and control

TL;DR: It is shown that fluctuation analysis, a method used in statistical physics, can be used to gain insight into asthma as a dynamic disease of the respiratory system, viewed as a set of interacting subsystems (eg, inflammatory, immunological, and mechanical).
Journal ArticleDOI

Improved arterial oxygenation with biologically variable or fractal ventilation using low tidal volumes in a porcine model of acute respiratory distress syndrome.

TL;DR: V (bv) improved Pa(O(2)) at lower peak airway pressure and IL-8 levels compared with V (c), which demonstrated an inverse power law indicating fractal behavior in this model of ARDS.
References
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Book

The Theory of Branching Processes

T. E. Harris
TL;DR: A review of the Galton and Watson mathematical model that applies probability theory to the effects of chance on the development of populations is given in this article, followed by a systematic development of branching processes, and a brief description of some of the important applications.
Book

Fractals and Disordered Systems

TL;DR: In this article, the authors present a model of 2D DLA growth in a 3D setting, which is based on the Laplace Equation (LE) and its variants.
Book

Fractal Physiology

TL;DR: The nature of fractals and the use of fractal instead of classical scaling concepts to describe the irregular surfaces, structures, and processes exhibited by physiological systems are described in this paper.
Journal ArticleDOI

Fractals and Disordered Systems

TL;DR: The substantial progress in the field of phase transitions and surface restructuring mainly based on new techniques and successfully accompanied by theoretical approaches is comprehensively documented in the 14 chapters of this volume with numerous references as discussed by the authors.
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