U
Urs Frey
Researcher at Boston Children's Hospital
Publications - 276
Citations - 13446
Urs Frey is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: Asthma & Wheeze. The author has an hindex of 54, co-authored 263 publications receiving 11245 citations. Previous affiliations of Urs Frey include University of Bern & University of Basel.
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Journal ArticleDOI
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more
TL;DR: Recommendations and guidelines on the evaluation and treatment of severe asthma in children and adults and coordinated research efforts for improved phenotyping will provide safe and effective biomarker-driven approaches to severe asthma therapy are provided.
Journal ArticleDOI
Definition, assessment and treatment of wheezing disorders in preschool children: An evidence-based approach
Paul L. P. Brand,Eugenio Baraldi,Hans Bisgaard,A. L. Boner,Jose A. Castro-Rodriguez,Adnan Custovic,J. de Blic,J. C. de Jongste,Ernst Eber,M. L. Everard,Urs Frey,Monika Gappa,Luis Garcia-Marcos,Jonathan Grigg,Warren Lenney,P. N. Le Souëf,Sheila A. McKenzie,Peter J. F. M. Merkus,Fabio Midulla,James Y. Paton,Giorgio Piacentini,Petr Pohunek,G. A. Rossi,Paul Seddon,Michael Silverman,Peter D. Sly,Stephen M. Stick,Arunas Valiulis,W.M.C. van Aalderen,Johannes H. Wildhaber,Göran Wennergren,Nicola Wilson,Zorica Zivkovic,Andrew Bush +33 more
TL;DR: Large well-designed randomised controlled trials with clear descriptions of patients are needed to improve the present recommendations on the treatment of these common syndromes.
Journal ArticleDOI
After asthma: redefining airways diseases
Ian D. Pavord,Richard Beasley,Alvar Agusti,Gary P. Anderson,Elisabeth H. Bel,Guy Brusselle,Guy Brusselle,Paul Cullinan,Adnan Custovic,Francine M. Ducharme,John V. Fahy,Urs Frey,Peter G. Gibson,Peter G. Gibson,Liam G Heaney,Patrick G. Holt,Marc Humbert,Marc Humbert,Clare M. Lloyd,Guy B. Marks,Fernando D. Martinez,Peter D. Sly,Erika von Mutius,Sally E. Wenzel,Heather J. Zar,Andrew Bush +25 more
TL;DR: The only way to make progress in the future is to be much more clear about the meaning of the labels used for asthma and to acknowledge the assumptions associated with them, which are believed to be the most important causes of the stagnation in key clinical outcomes observed in the past 10 years.
Journal ArticleDOI
Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort
Dominick E. Shaw,Ana R. Sousa,Stephen J. Fowler,Louise Fleming,Graham Roberts,Graham Roberts,Julie Corfield,Julie Corfield,Ioannis Pandis,Aruna T. Bansal,Elisabeth H. Bel,Charles Auffray,Chris Compton,Hans Bisgaard,Enrica Bucchioni,Massimo Caruso,Pascal Chanez,Barbro Dahlén,Sven-Erik Dahlén,Kerry Dyson,Urs Frey,Thomas Geiser,Maria Gerhardsson de Verdier,David Gibeon,Yike Guo,Simone Hashimoto,Gunilla Hedlin,E. Jeyasingham,P.P. Hekking,Tim Higenbottam,Ildiko Horvath,Alan J. Knox,Norbert Krug,Veit J. Erpenbeck,L. Larsson,Nikos Lazarinis,John G. Matthews,Roelinde Middelveld,Paolo Montuschi,Jacek Musiał,David Myles,Laurie Pahus,Thomas Sandström,Wolfgang Seibold,Florian Singer,Karin Strandberg,Jørgen Vestbo,Nadja Hawwa Vissing,Christophe von Garnier,Ian M. Adcock,Scott Wagers,Anthony Rowe,Peter H. Howarth,Ariane H. Wagener,Ratko Djukanovic,Peter J. Sterk,Kian Fan Chung +56 more
TL;DR: U-BIOPRED is characterised by poor symptom control, increased comorbidity and airway inflammation, despite high levels of treatment, and is well suited to identify asthma phenotypes using the array of "omic" datasets that are at the core of this systems medicine approach.
Journal ArticleDOI
Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline
Fernando Holguin,Juan Carlos Cardet,Kian Fan Chung,Sarah Diver,Diogenes S. Ferreira,Diogenes S. Ferreira,Anne M. Fitzpatrick,Mina Gaga,Liz Kellermeyer,Sandhya Khurana,Shandra L Knight,Vanessa M. McDonald,Rebecca L. Morgan,Victor E. Ortega,David Rigau,Padmaja Subbarao,Thomy Tonia,Ian M. Adcock,Eugene R. Bleecker,Christopher E. Brightling,Louis-Philippe Boulet,Michael D. Cabana,Mario Castro,Pascal Chanez,Adnan Custovic,Ratko Djukanovic,Urs Frey,Betty Frankemölle,Peter G. Gibson,Dominique Hamerlijnck,Nizar N. Jarjour,Satoshi Konno,Huahao Shen,Cathy Vitary,Andrew Bush +34 more
TL;DR: Clinical recommendations for the management of severe asthma are provided and the use of novel therapies for severe asthma, specifically biologicals for type 2 high asthma, and antimuscarinic agents and macrolides, as well as on biomarkers for predicting treatment response are made.