Journal ArticleDOI
Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice.
Reinhard L. Friede,T. Samorajski +1 more
TLDR
A series of regression analyses indicated that axon caliber correlates best with the sum of the number of neurofilaments and microtubules per fiber, which was only slightly better than that for neurofilament alone.Citations
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Cerebrospinal fluid and plasma biomarkers in Alzheimer disease.
TL;DR: The rationales behind and the diagnostic performances of the core cerebrospinal fluid biomarkers for AD, namely total tau, phosphorylated tau and the 42 amino acid form of amyloid-β are presented.
Journal ArticleDOI
CSF and blood biomarkers for the diagnosis of Alzheimer's disease: a systematic review and meta-analysis
Bob Olsson,Ronald Lautner,Ulf Andreasson,Annika Öhrfelt,Erik Portelius,Maria Bjerke,Maria Bjerke,Mikko Hölttä,Christoffer Rosén,Caroline Olsson,Gabrielle Strobel,Elizabeth Wu,Kelly Dakin,Max Petzold,Max Petzold,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg +17 more
TL;DR: The core CSF biomarkers of neurodegeneration (T-tau, P-tAU, and Aβ42), CSF NFL, and plasma T-t Tau were strongly associated with Alzheimer's disease and the core biomarkers were strong associated with mild cognitive impairment due to Alzheimer's Disease.
Journal ArticleDOI
A Structural Scaffolding of Intermediate Filaments in Health and Disease
Elaine Fuchs,Don W. Cleveland +1 more
TL;DR: Evidence is reviewed here that intermediate filaments provide a flexible intracellular scaffolding whose function is to structure cytoplasm and to resist stresses externally applied to the cell.
Journal ArticleDOI
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Paul N. Hoffman,Raymond J. Lasek +1 more
TL;DR: The demonstration on SDS gels that the slow component of axonal transport is composed of a small number of polypeptides which have identical molecular weights in neurons from different mammalian species suggests that these polypePTides comprise fundamental structures of vertebrate neurons.
Journal ArticleDOI
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cells.
TL;DR: Close intercellular contacts between myelinating Schwann cells and axons modulate a kinase-phosphatase system acting on neurofilaments and possibly other substrates that sculpts the axon-altering functional architecture, electrical properties, and neuronal morphologies.
References
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Journal ArticleDOI
A simplified lead citrate stain for use in electron microscopy.
TL;DR: This communication reports the use of a commercially available lead citratO to eliminate the lead citrate stain in electron microscopy.
Journal ArticleDOI
A new epoxy embedment for electron microscopy.
James A. Freeman,Ben O. Spurlock +1 more
TL;DR: A new epoxy embedding mixture has been developed utilizing Maraglas 655 and Cardolite NC-513 with benzyldimethylamine (BDMA) as a curing agent that permits cellular preservation comparable to that obtained with Epon 812, ease of preparation of tissues, a wide range of miscibility, low viscosity, and, most important, easy of sectioning on a Porter-Blum microtome.
Journal ArticleDOI
Myelin formation in the sciatic nerve of the rat. A quantitative electron microscopic, histochemical and radioautographic study.
R. L. Friede,T. Samorajski +1 more
Journal ArticleDOI
Microtubules and filaments in the axons and astrocytes of early postnatal rat optic nerves.
Alan Peters,James E. Vaughn +1 more
TL;DR: Observed changes in the population of microtubules and filaments within the cytoplasm of maturing axons and astrocytes have been studied during the early postnatal development of rat optic nerves suggest that the Filaments within axonsand astroCytes may be formed by the breakdown ofmicrotubules.
Journal ArticleDOI
Relation between the number of myelin lamellae and axon circumference in fibers of vagus and sciatic nerves of mice.
Reinhard L. Friede,T. Samorajski +1 more
TL;DR: Nerve fiber populations of the vagus and sciatic nerves of mice were classified according to the number of myelin lamellae present in the sheaths to provide a more sensitive procedure for the analysis of individual fibers and better control over the technical factors involved in tissue processing.
Related Papers (5)
Control of axonal caliber by neurofilament transport.
The slow component of axonal transport. Identification of major structural polypeptides of the axon and their generality among mammalian neurons.
Paul N. Hoffman,Raymond J. Lasek +1 more