Journal ArticleDOI
Axonal sprouting accompanies functional reorganization in adult cat striate cortex.
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It is reported here that structural changes in the form of axonal sprouting of long-range laterally projecting neurons accompany topographic remodelling of the visual cortex.Abstract:
Removal of sensory input from a focal region of adult neocortex can lead to a large reorganization of cortical topography within the deprived area during subsequent months. Although this form of functional recovery is now well documented across several sensory systems, the underlying cellular mechanisms remain elusive. Weeks after binocular retinal lesions silence a corresponding portion of striate cortex in the adult cat, this cortex again becomes responsive, this time to retinal loci immediately outside the scotoma. Earlier findings showed a lack of reorganization in the lateral geniculate nucleus and an inadequate spread of geniculocortical afferents to account for the cortical reorganization, suggesting the involvement of intrinsic cortical connections. We investigated the possibility that intracortical axonal sprouting mediates long-term reorganization of cortical functional architecture. The anterograde label biocytin was used to compare the density of lateral projections into reorganized and non-deprived cortex. We report here that structural changes in the form of axonal sprouting of long-range laterally projecting neurons accompany topographic remodelling of the visual cortex.read more
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Journal ArticleDOI
Fractional amplitude of low-frequency fluctuation changes in monkeys with spinal cord injury: A resting-state fMRI study☆
Jia-Sheng Rao,Manxiu Ma,Can Zhao,Aifeng Zhang,Zhaoyang Yang,Zhaoyang Yang,Zuxiang Liu,Xiaoguang Li,Xiaoguang Li +8 more
TL;DR: Analysis of the resting-state fMRI provides evidence of abnormal spontaneous brain activations in primates with SCI, which may help to understand the pathophysiologic mechanisms underlying the changes in neural plasticity in the central nervous system after SCI.
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Learning: Neuronal dynamics and perceptual learning
TL;DR: Perceptual learning is accompanied by changes in the properties of individual neurons and in the functional cortical architecture; these are observed in a number of cortical areas, over short and long time scales.
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Age-dependent alterations in CRMP2 and CRMP4 protein expression profiles in cat visual cortex.
Lieselotte Cnops,Tjing-Tjing Hu,Kalina Burnat,Kalina Burnat,Estel Van der Gucht,Lutgarde Arckens +5 more
TL;DR: The present results clearly illustrate that CRMP2 and CRMP4 may play an important role in visual cortex, possibly providing different classes of neurons with the potential to form a functionally meaningful network, not only during development, but also in adulthood, coincident with the belief thatCRMPs are involved in neurite growth and guidance.
Journal ArticleDOI
Rehabilitation Approaches in Macular Degeneration Patients.
Marcello Maniglia,Marcello Maniglia,Marcello Maniglia,Benoit R. Cottereau,Benoit R. Cottereau,Vincent Soler,Yves Trotter,Yves Trotter +7 more
TL;DR: It is argued that with an appropriate experimental and training protocol that is adapted to each patient needs, PL can offer fascinating opportunities for the development of simple, non-expensive rehabilitation approaches a large spectrum of visual functions in AMD patients.
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Cortical Changes Following Spinal Cord Injury with Emphasis on the Nogo Signaling System
TL;DR: Human and animal studies of spinal cord injury are reviewed, with special emphasis on the contribution of the Nogo signaling system to cortical plasticity.
References
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Somatosensory cortical map changes following digit amputation in adult monkeys
Michael M. Merzenich,R. J. Nelson,Michael P. Stryker,Max S. Cynader,Axel Schoppmann,John M. Zook +5 more
TL;DR: The cortical representations of the hand in area 3b in adult owl monkeys were defined with use of microelectrode mapping techniques 2–8 months after surgical amputation of digit 3, or of both digits 2 and 3.
Journal ArticleDOI
Plasticity in the frequency representation of primary auditory cortex following discrimination training in adult owl monkeys
TL;DR: It is demonstrated that attended natural stimulation can modify the tonotopic organization of Al in the adult primate, and that this alteration is correlated with changes in perceptual acuity.
Journal ArticleDOI
Columnar specificity of intrinsic horizontal and corticocortical connections in cat visual cortex
TL;DR: The extent of the horizontal connections, which allows single cells to integrate information over larger parts of the visual field than that covered by their receptive fields, and the functional specificity of the connections, suggests possible roles for these connections in visual processing.
Journal ArticleDOI
Massive cortical reorganization after sensory deafferentation in adult macaques
Tim P. Pons,Preston E. Garraghty,Alexander K. Ommaya,Jon H. Kaas,Edward Taub,Mortimer Mishkin +5 more
TL;DR: The results show the need for a reevaluation of both the upper limit of cortical reorganization in adult primates and the mechanisms responsible for it.
Journal ArticleDOI
Morphology and intracortical projections of functionally characterised neurones in the cat visual cortex
TL;DR: The neuronal structure and connectivity underlying receptive field organisation of cells in the cat visual cortex have been investigated using a micropipette filled with a histochemical marker to visualise the dendritic and axonal arborisations of functionally identified neurones.