Journal ArticleDOI
Binding of phencyclidine to rat membranes: Technical aspect
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TLDR
[3H]Phencyclidine has a tendency to adsorb to filters used in binding experiments, and the spinal binding techniques that should be used to overcome this difficulty are described.About:
This article is published in European Journal of Pharmacology.The article was published on 1980-11-07. It has received 27 citations till now.read more
Citations
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Journal ArticleDOI
Multiple opiate receptors: emerging concepts.
TL;DR: The constellation of neuropharmacological actions of a particular opioid ligand may reflect its various potencies at a combination of μ, δ, K, and σ receptors.
Journal ArticleDOI
[3H]TCP: a new tool with high affinity for the PCP receptor in rat brain.
Jacques Vignon,Jacques Vignon,Robert Chicheportiche,Robert Chicheportiche,Michèle Chicheportiche,Michèle Chicheportiche,Jean-Marc Kamenka,Jean-Marc Kamenka,Patrick Geneste,Patrick Geneste,Michel Lazdunski,Michel Lazdunski +11 more
TL;DR: The binding properties to rat brain membranes of [3H]TCP, a PCP derivative, are described and it is found that it has a better affinity for PCP binding sites than PCP itself.
Journal ArticleDOI
[3H]Thienyl-phencyclidine ([3H]TCP) binds to two different sites in rat brain. Localization by autoradiographic and biochemical techniques
Jacques Vignon,Alain Privat,Isabelle Chaudieu,Alain R. Thierry,Jean-Marc Kamenka,Robert Chicheportiche +5 more
TL;DR: Results obtained with SKF-10,047 (N-allylnormetazocine) seem to indicate that TCP and sigma-receptors are different, and two distinct binding sites for [3H]TCP exist: one of high affinity in the forebrain and a second one in the hindbrain and the spinal cord, involved in the extrapyramidal behavior induced by PCP and congeneers.
Journal ArticleDOI
Specific Binding of [3H] phencyclidine in rat central nervous tissue: further characterization and technical considerations
TL;DR: The interaction of phencyclidine (PCP) with its specific receptor sites in the central nervous system has been further characterized and the finding that (+)-ketamine is four-fold more potent than (--ketamine in displacing specifically bound [3H]PCP was demonstrated.
References
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Journal ArticleDOI
Specific [3H]phencyclidine binding in rat central nervous system
Stephen R. Zukin,R. S. Zukin +1 more
TL;DR: [3H]PCP binding was most enriched in crude synaptosomal subcellular fractions, and was about three times higher in hippocampus than in cervical spinal cord, suggesting that PCP may exert its effects on the central nervous system via binding to specific brain receptor sites.
Journal ArticleDOI
Interaction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.
TL;DR: Phencyclidine bound to its receptor is not displaced by the classical neurotransmitters or neuromodulators, and there is a good correlation between the apparent affinities of a series of phencyclidine analogs for the Phencyclidine receptor and the pharacological activities of these analogs as measured by the rotarod assay.
Journal ArticleDOI
Interaction of phencyclidines with the muscarinic and opiate receptors in the central nervous system.
TL;DR: Phencyclidine produces long-lasting psychosis thought to resemble schizophrenia more than any produced by other psychedelics 1~ and exaggerates psychopathology.
Journal ArticleDOI
“Specific binding” of 3H-phencyclidine: Artifacts of the rapid filtration method
Saul Maayani,Harel Weinstein +1 more
TL;DR: It is found that 3 H-PCP binds to GF/B glass fiber filters in a manner indistinguishable from “specific binding”, and it is concluded that the artifacts created in this case by the rapid filtration method render it unsuitable for labeling the pharmacologically relevant binding sites of 3 H -PCP.
Journal ArticleDOI
Compared properties of central and peripheral binding sites for phencyclidine.
TL;DR: Affinities of phencyclidines for the brain receptor but not those for peripheral organs are correlated with the pharmacological activities of phen cyclidines as measured in the rotarod test.
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Specific [3H]phencyclidine binding in rat central nervous system
Stephen R. Zukin,R. S. Zukin +1 more