Journal ArticleDOI
Biodegradable internal fixation plates enabled with X‐ray visibility by a radiopaque layer of β‐tricalcium phosphate and poly (lactic‐co‐glycolic acid)
Catherine Shasteen,Seok Min Kwon,Keun Yung Park,Sun Young Jung,Seung Ho Lee,Chun Gwon Park,Myung Hun Kim,Suk Wha Kim,Woo-Chan Son,Tae Hyun Choi,Young Bin Choy +10 more
TLDR
The radiopaque plate prepared in this work is a promising fixation device enabled with both X-ray visibility and biodegradability, and shows the overall biocompatibility 6 months after implantation.Abstract:
Biodegradable polymer plates can be clinically used as an alternative to metal plates (e.g., titanium) for internal fixation, which, however, are not visible with X-ray imaging, often used for post-operative diagnostics. In this study, therefore, we prepared a biodegradable plate enabled with X-ray visibility by attaching a radiopaque layer on a biodegradable fixation plate in clinical use (Inion, Finland). A radiopaque layer was made of a fine powder of a radiopaque agent, β-tricalcium phosphate (TCP) and a biodegradable binder material, poly (lactic-co-glycolic acid) (PLGA), which were physically mixed without change in their chemical structure. The radiopacity increased as we increased the layer thicknesses from 0.5 mm to 1.3 mm. Regardless of layer thickness, however, the radiopacity decreased with time both in vitro and in vivo due to decreasing density of TCP in the layer by swelling and degradation of a binder material, PLGA. The in vivo study with rabbits revealed that a discernible image of the radiopaque plate could be obtained by X-ray for up to 21 days, also showing the overall biocompatibility 6 months after implantation. Therefore, we conclude that the radiopaque plate prepared in this work is a promising fixation device enabled with both X-ray visibility and biodegradability. © 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 2013.read more
Citations
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Journal ArticleDOI
Aliphatic polyesters for medical imaging and theranostic applications.
TL;DR: A state-of-the-art of polyester-based imaging systems focusing on the strategies relying on CAs/IPs encapsulation in nanoparticles, micelles, dendrimers or capsules is presented.
Journal ArticleDOI
Mucoadhesive microparticles with a nanostructured surface for enhanced bioavailability of glaucoma drug.
Chun Gwon Park,Young Kook Kim,Mi Jeung Kim,Min Park,Myung Hun Kim,Seung Ho Lee,Sung Yoon Choi,Wonseok Lee,You Jung Chung,Young Eun Jung,Ki Ho Park,Ki Ho Park,Young Bin Choy,Young Bin Choy +13 more
TL;DR: In this paper, the authors proposed a mucoadhesive microparticles with a nanostructured surface as potential carriers for delivery of brimonidine, an ocular drug for glaucoma treatment.
Journal ArticleDOI
Radiopaque poly(ε-caprolactone) as additive for X-ray imaging of temporary implantable medical devices
Rémi Samuel,Edouard Girard,Edouard Girard,Grégory Chagnon,Grégory Chagnon,Stéphane Dejean,Denis Favier,Denis Favier,Jean Coudane,Benjamin Nottelet +9 more
TL;DR: Their potential as radio-opacifying additive for medical devices was evaluated by preparing polymeric blends of PCL-TIB with various (co)polyesters and cytocompatibility was assessed by evaluating the proliferation of L929 fibroblasts on the blends.
PatentDOI
Radioopaque, iodine functionalized phenylalanine-based poly(ester urea)s
Matthew L. Becker,Shan Li +1 more
TL;DR: In one or more embodiment, the present invention provides iodine-functionalized phenylalanine-based poly(ester urea)s (PEUs) and related methods for their synthesis and use as mentioned in this paper that are metal free, degradable, radiopaque and suitable for use in surgical implants and other medical devices used within a patient.
References
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