C
Chun Gwon Park
Researcher at Sungkyunkwan University
Publications - 80
Citations - 2958
Chun Gwon Park is an academic researcher from Sungkyunkwan University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 19, co-authored 59 publications receiving 1720 citations. Previous affiliations of Chun Gwon Park include Harvard University & Seoul National University.
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Journal ArticleDOI
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.
Jean Albrengues,Mario A. Shields,David Ng,Chun Gwon Park,Alexandra Ambrico,Morgan E. Poindexter,Priya Upadhyay,Dale Uyeminami,Arnaud Pommier,Victoria Küttner,Emilis Bružas,Emilis Bružas,Laura Maiorino,Laura Maiorino,Carmelita Bautista,Ellese M. Carmona,Phyllis A. Gimotty,Douglas T. Fearon,Douglas T. Fearon,Douglas T. Fearon,Kenneth Chang,Scott K. Lyons,Kent E. Pinkerton,Lloyd C. Trotman,Michael S. Goldberg,Johannes T.-H. Yeh,Mikala Egeblad +26 more
TL;DR: The data implicate NETs and NET-mediated ECM remodeling as critical mediators of inflammation-induced awakening in mouse models of dormancy and propose that NETs awaken cancer by concentrating neutrophil proteases at the ECM protein laminin.
Journal ArticleDOI
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Daniela Schmid,Chun Gwon Park,Christina A. Hartl,Nikita Subedi,Adam N.R. Cartwright,Regina Bou Puerto,Yiran Zheng,James Maiarana,Gordon J. Freeman,Kai W. Wucherpfennig,Darrell J. Irvine,Darrell J. Irvine,Michael S. Goldberg +12 more
TL;DR: In this article, antibody-targeted nanoparticles that bind to CD8+ T cells in the blood, lymphoid tissues, and tumors of mice are successfully targeted in the circulation and tumor.
Journal Article
T cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Daniela Schmid,Chun Gwon Park,Christina A. Hartl,Nikita Subedi,Adam N.R. Cartwright,Regina Bou Puerto,James Maiarana,Gordon J. Freeman,Kai W. Wucherpfennig,Michael S. Goldberg,Yiran Zheng,Darrell J. Irvine +11 more
TL;DR: PD-1-targeting nanoparticles containing a TGFβ inhibitor or a TLR7/8 agonist are used to deliver these payloads to T cells or via T cells to the tumor microenvironment, leading to anti-tumor efficacy in vivo.
Journal ArticleDOI
Extended release of perioperative immunotherapy prevents tumor recurrence and eliminates metastases.
Chun Gwon Park,Chun Gwon Park,Christina A. Hartl,Daniela Schmid,Ellese M. Carmona,Hye-Jung Kim,Michael S. Goldberg +6 more
TL;DR: Perioperative delivery of immunotherapy prevents local tumor recurrence and eliminates established spontaneous metastases and suggests that the perioperative setting may prove to be a useful context for immunotherapy, particularly when the release of the therapy is extended locally.
Journal ArticleDOI
Protein-Based Nanoparticles as Drug Delivery Systems.
TL;DR: Protein nanoparticles can be generated using proteins, and are prepared through emulsion, electrospray, and desolvation methods, and the corresponding advantages and disadvantages are compared.