Book ChapterDOI
Biological Roles of Keratan Sulfate Proteoglycans
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This article is published in Carbohydrates in Chemistry and Biology.The article was published on 2008-04-24. It has received 4 citations till now. The article focuses on the topics: Keratan sulfate & Glycosaminoglycan.read more
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Journal ArticleDOI
Knockdown of Zebrafish Lumican Gene (zlum) Causes Scleral Thinning and Increased Size of Scleral Coats
Lung-Kun Yeh,Chia-Yang Liu,Winston W.-Y. Kao,Chang-Jen Huang,Fung-Rong Hu,Chung-Liang Chien,I-Jong Wang +6 more
TL;DR: Zebrafish is chosen as an animal model to elucidate the role of lumican in the development of axial myopia and the observation suggests that zebrafish can be used as an in vivo model for screening compounds in treating myopia.
Journal ArticleDOI
Thyroxine affects expression of KSPG-related genes, the carbonic anhydrase II gene, and KS sulfation in the embryonic chicken cornea.
Abigail H. Conrad,Yuntao Zhang,Amy R Walker,Lisa A Olberding,Ann Hanzlick,Andrea J Zimmer,Raul Morffi,Gary W. Conrad +7 more
TL;DR: Thyroxine modifies expressions of KSPG synthesis and carbonic anhydrase genes during transparency development and whether these expressions are altered when E9 embryos are treated with T4 is investigated.
Journal ArticleDOI
The keratocan gene is expressed in both ocular and non-ocular tissues during early chick development
Abigail H. Conrad,Gary W. Conrad +1 more
TL;DR: The hypothesis that keratocan, or ker atocan with minimally sulfated KS chains, may play a role in structuring ECM for early embryonic cell and neuronal migrations is suggested.
Journal ArticleDOI
On-target derivatization of keratan sulfate oligosaccharides with pyrenebutyric acid hydrazide for MALDI-TOF/TOF-MS.
Yuntao Zhang,Takeo Iwamoto,Gary A. Radke,Yutaka Kariya,Kiyoshi Suzuki,Abigail H. Conrad,John M. Tomich,Gary W. Conrad +7 more
TL;DR: MALDI-(time-of-flight)-TOF spectra of labeled KS oligosaccharides revealed that significantly improved ionization can be accomplished through derivatization with pyrenebutyric acid hydrazide (PBH), and the most abundant peak in each spectrum corresponds to the singly charged molecular ion.