Journal ArticleDOI
The keratocan gene is expressed in both ocular and non-ocular tissues during early chick development
Abigail H. Conrad,Gary W. Conrad +1 more
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TLDR
The hypothesis that keratocan, or ker atocan with minimally sulfated KS chains, may play a role in structuring ECM for early embryonic cell and neuronal migrations is suggested.About:
This article is published in Matrix Biology.The article was published on 2003-06-01. It has received 29 citations till now. The article focuses on the topics: Keratocan & Embryonic mesenchyme.read more
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Journal ArticleDOI
Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Renato V. Iozzo,Liliana Schaefer +1 more
TL;DR: The proposed nomenclature encompasses forty-three distinct proteoglycan-encoding genes and many alternatively-spliced variants and is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
Journal ArticleDOI
The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assembly.
Shoujun Chen,David E. Birk +1 more
TL;DR: Small leucine‐rich proteoglycans regulate assembly of the extracellular matrix, which defines the microenvironment, modulating both the extracllular matrix and cellular functions, with an impact on tissue function.
Journal ArticleDOI
Development of the corneal stroma, and the collagen–proteoglycan associations that help define its structure and function
TL;DR: This article will review corneal developmental dynamics from a structural perspective, consider the roles and interrelationships of collagens and proteoglycans, and comment on contemporary concepts and current challenges pertinent to developmental processes that result in an optically clear, mature cornea.
Book ChapterDOI
Corneal Development: Different Cells from a Common Progenitor
TL;DR: This review summarizes historical and current research to provide an overview of the genesis of the cellular layers of the cornea, corneal innervation, and avascularity.
Journal ArticleDOI
Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance
TL;DR: This review focuses on describing SLRP family members involvement in neural development with a brief summary of their role in non‐neural ocular tissues and in response to neural injury.
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Journal ArticleDOI
A series of normal stages in the development of the chick embryo
TL;DR: The preparation of a series of normal stages of the chick embryo does not need justification at a time when chick ernbryos are not only widely used in descriptive and experimental embryology but are proving to be increasingly valuable in medical research, as in work on viruses and cancer.
Journal ArticleDOI
Expression of a Delta homologue in prospective neurons in the chick
TL;DR: It is shown that C-Delta-1 is expressed in prospective neurons during neurogenesis, as new cells are being born and their fates decided, suggesting that both the Delta/ Notch signalling mechanism and its role in Neurogenesis have been conserved in vertebrates.
Journal ArticleDOI
Lumican Regulates Collagen Fibril Assembly: Skin Fragility and Corneal Opacity in the Absence of Lumican
Shukti Chakravarti,Terry Magnuson,Jonathan H. Lass,Karl J. Jepsen,Christian LaMantia,Heidi Carroll +5 more
TL;DR: A crucial role is established for lumican in the regulation of collagen assembly into fibrils in various connective tissues and the development of a highly organized collagenous matrix and corneal transparency.
Journal ArticleDOI
The biology of the small leucine-rich proteoglycans. Functional network of interactive proteins.
TL;DR: The focus is on the “functional network” created by these molecules in tissues, on genetic evidence for their functional roles during ontogeny, and on their activities as modulators of complex pathological processes such as fibrosis and cancer growth.
Journal ArticleDOI
The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain.
TL;DR: It is shown that NCC-derived pericytes and smooth muscle cells are distributed in a sharply circumscribed sector of the vasculature of the avian embryo, suggesting that the vertebrate subphylum may have exploited the exceptionally broad range of developmental potentialities and the plasticity of NCCs in head remodelling that resulted in the growth of the forebrain.