K
Kenji Uchimura
Researcher at Lille University of Science and Technology
Publications - 89
Citations - 4083
Kenji Uchimura is an academic researcher from Lille University of Science and Technology. The author has contributed to research in topics: Heparan sulfate & Keratan sulfate. The author has an hindex of 30, co-authored 83 publications receiving 3600 citations. Previous affiliations of Kenji Uchimura include university of lille & Wako Pure Chemical Industries, Ltd.
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Journal ArticleDOI
Minocycline selectively inhibits M1 polarization of microglia
Kazuyoshi Kobayashi,Shiro Imagama,Tomohiro Ohgomori,Kenichi Hirano,Kenji Uchimura,Kazuma Sakamoto,Akihiro Hirakawa,Hideyuki Takeuchi,Akio Suzumura,Naoki Ishiguro,Kenji Kadomatsu +10 more
TL;DR: It is indicated that minocycline selectively inhibits the microglia polarization to a proinflammatory state, and provides a basis for understanding pathogeneses of many diseases accompanied by microglial activation.
Journal ArticleDOI
Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans
TL;DR: The cloning of a full-length cDNA encoding the human ortholog (HSulf-1) of the developmentally regulated putative sulfatases is reported, establishing that the mammalian Sulfs areextracellular endosulfatases with strong potential for modulating the interactions of heparan sulfate proteoglycans in the extracellular microenvironment.
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HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
Kenji Uchimura,Megumi Morimoto-Tomita,Annette Bistrup,Jessica Li,Malcolm Lyon,John T. Gallagher,Zena Werb,Steven D. Rosen +7 more
TL;DR: Sulf-2 is validated as a new tool for deciphering the sulfation requirements in the interaction of protein ligands with heparin/HSPGs and expand the range of potential biological activities of this enzyme.
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A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules.
Kenji Uchimura,Jean-Marc Gauguet,Mark S. Singer,Durwin Tsay,Reiji Kannagi,Takashi Muramatsu,Ulrich H. von Andrian,Steven D. Rosen +7 more
TL;DR: This work has demonstrated elimination of both peripheral node addressin and sialyl 6-sulfo Lewis X in high endothelial venules, considerably reduced lymphocyte homing to peripheral lymph nodes and reduced sticking of lymphocytes along high vascular venules.
Journal ArticleDOI
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules.
Hiroto Kawashima,Bronislawa Petryniak,Nobuyoshi Hiraoka,Junya Mitoma,Valerie Huckaby,Jun Nakayama,Kenji Uchimura,Kenji Kadomatsu,Takashi Muramatsu,John B. Lowe,Minoru Fukuda +10 more
TL;DR: The essential function of GlcNAc6ST-1 and Glcnac6 ST-2 in L-selectin ligand biosynthesis in high endothelial venules and their importance in immune surveillance are demonstrated.