Biopharmaceutical characterisation of ciprofloxacin-metallic ion interactions: Comparative study into the effect of aluminium, calcium, zinc and iron on drug solubility and dissolution
Aleksandra Stojković,Lidia Tajber,Krzysztof J. Paluch,Zorica Djuric,Jelena Parojčić,Owen I. Corrigan +5 more
TLDR
Comparison in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.Abstract:
Ciprofloxacin bioavailability may be reduced when ciprofloxacin is co-administered with metallic ion containing preparations. In our previous study, physicochemical interaction between ciprofloxacin and ferrous sulphate was successfully simulated in vitro. In the present work, comparative in vitro ciprofloxacin solubility and dissolution studies were performed in the reactive media containing aluminium hydroxide, calcium carbonate or zinc sulphate. Solid phases collected from the dissolution vessel with aluminium hydroxide, calcium carbonate and zinc sulphate were investigated for their properties. The results obtained indicate that different types of adducts may form and retard ciprofloxacin solubility and dissolution. In the case of aluminium, no phase changes were observed. The solid phase generated in the presence of calcium carbonate was identified as hydrated ciprofloxacin base. Similarly to iron, a new complex consistent with Zn(SO4)2(Cl)2(ciprofloxacin)2 × nH2O stoichiometry was generated in the presence of relatively high concentrations of ciprofloxacin hydrochloride and zinc sulphate, indicating that small volume dissolution experiments can be useful for biorelevant dissolution tests.read more
Citations
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Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach
Deepak Rawtani,Gaurav Pandey,Maithri Tharmavaram,Pooja Pathak,Satyaprasad Akkireddy,Yadvendra K. Agrawal +5 more
TL;DR: In this article, Halloysite Nanotubes (HNT) post functionalization with 3-aminopropyltriethoxysilane (APTES) were used as a carrier for entrapment of ciprofloxacin.
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Synthesis, coating, and drug-release of hydroxyapatite nanoparticles loaded with antibiotics.
TL;DR: This approach provides a purely bioactive coating with drug delivery properties in a simple, economic, and fast process and shows superior bioactivity with enhanced precipitation of HAp crystals along with inorganic minerals, such as Mg2+, Na+, and Cl-.
Journal ArticleDOI
In vitro biopharmaceutical evaluation of ciprofloxacin/metal cation complexes for pulmonary administration
TL;DR: In this paper, CIP was chosen as a representative fluoroquinolones (FQ) and 5 cations (Ca2+, Mg2+, Zn2+, Al3+, Cu2+) were selected to study the complexation and its effects on permeability, antimicrobial efficacy and cell toxicity.
Journal ArticleDOI
Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation
TL;DR: In this article , a low-cost chitin-biocalcium composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
Journal ArticleDOI
Chitin-biocalcium as a novel superior composite for ciprofloxacin removal: Synergism of adsorption and flocculation.
TL;DR: In this article, a low-cost chitin-biocalcium composite was developed by a facile alkali activation process from shell waste for typical antibiotics ciprofloxacin (CIP) removal.
References
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Journal ArticleDOI
The interactions of metal ions with quinolone antibacterial agents
TL;DR: The quinolones are a group of synthetic antibacterial agents structurally related to nalidixic acid as mentioned in this paper, and the absorption of these agents is lower when they are consumed simultaneously with magnesium or aluminium antacids.
Journal ArticleDOI
Pharmacokinetics of ciprofloxacin after oral and parenteral administration.
TL;DR: In 12 fasting volunteers, the pharmacokinetics of ciprofloxacin were determined after the administration of 50, 100, and 750 mg orally as well as 50 and 100 mg intravenously over 15 min, indicating a first-pass effect of the liver.
Journal ArticleDOI
Effects of aluminum and magnesium antacids and ranitidine on the absorption of ciprofloxacin
David E. Nix,David E. Nix,William A. Watson,William A. Watson,Michelle E. Lener,Michelle E. Lener,R. Wayne Frost,R. Wayne Frost,George Krol,George Krol,Harvey R. Goldstein,Harvey R. Goldstein,John T. Lettieri,John T. Lettieri,Jerome J. Schentag,Jerome J. Schentag +15 more
TL;DR: Ranitidine is suggested as an alternative to antacids for patients receiving treatment with ciprofloxacin as the extent of this interaction appears to increase as the time between administration of the two drugs decreases.
Journal ArticleDOI
Effect of ferrous sulfate and multivitamins with zinc on absorption of ciprofloxacin in normal volunteers.
TL;DR: Ferrous sulfate and multivitamins with zinc significantly impaired the absorption of ciprofloxacin; the effect of ferrous sulphate is likely to be clinically significant; the responsible component of multivitamin with zinc requires additional study.
Journal ArticleDOI
Pharmacokinetic profiles of ciprofloxacin after single intravenous and oral doses
TL;DR: Ciprofloxacin was administered to 12 healthy male volunteers at doses of 300 and 400 mg intravenously (i.v.) and 500 and 750 mg orally in a randomized, double-blind, single-dose, four-period crossover study.
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