Journal ArticleDOI
Bis heterocycles as potential chemotherapeutic agents. X. Synthesis of bis(4-arylthiosemicarbazido)-, bis(2-arylamino-1,3,4-thiadiazol-5-yl) and bis(4-aryl-1,2,4-triazolin-3-thione-5-yl)pentanes and related compounds
TLDR
Synthesis of several bis(4-arylthiosemicarbazido- 1, bis(2-arylamino-1,3,4thiadiazol-5-yl)- 5 and bis( 4-aryl-1.2,4-triazolin-3-thione-5yl)- 2 pentanes is described.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 1990-02-01. It has received 50 citations till now. The article focuses on the topics: Pentanes & Aryl.read more
Citations
More filters
Journal ArticleDOI
Sulfonamide-1,2,4-triazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies.
Iraj Rahavi Ezabadi,Charalabos Camoutsis,Panagiotis Zoumpoulakis,Athina Geronikaki,Marina Soković,Jasmina Glamočilija,Ana Ćirić +6 more
TL;DR: A series of 10 new 5-[2-(substituted sulfamoyl)-4,5-dimethoxy-benzyl]-4aryl-s-triazole-3-thiones synthesized and evaluated for in vitro antifungal and antibacterial activity found that Gram (-) bacteria seem to be more sensitive to these compounds than Gram (+) species.
Journal ArticleDOI
Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety.
Prakash Karegoudar,D. Jagdeesh Prasad,Mithun Ashok,Manjathuru Mahalinga,Boja Poojary,Bantwal Shivarama Holla +5 more
TL;DR: The reaction of 2,3,5-trichlorobenzoic acid hydrazide with carbon disulfide and potassium hydroxide followed by treatment with hydrazine hydrate afforded 3-(2,3.5- trichlorophenyl)-4-amino-1,2,4-triazole-5-thione (6).
Journal ArticleDOI
Synthesis and antimicrobial activity of some 1,2,4-triazole-3-mercaptoacetic acid derivatives.
TL;DR: Compound 4f showed antibacterial activity against some bacteria and the in vitro antimycobacterial activity of the new compounds against Mycobacterium tuberculosis H37Rv was evaluated employing the BACTEC 460 radiometric system.
Journal ArticleDOI
Synthesis, antimicrobial evaluation and QSAR analysis of novel nalidixic acid based 1,2,4-triazole derivatives
TL;DR: Based on the QSAR analysis, it is indicative that lipophilic and steric parameters are the pre-requisites for these molecules to act as potent antimicrobial agents.
Journal ArticleDOI
Synthesis of some novel pyridine compounds containing bis-1,2,4-triazole/thiosemicarbazide moiety and investigation of their antioxidant properties, carbonic anhydrase, and acetylcholinesterase enzymes inhibition profiles.
Nilufer Bulut,Umit M. Kocyigit,İbrahim Halil Geçibesler,Taner Daştan,Huseyin Karci,Parham Taslimi,Sevgi Durna Daştan,İlhami Gülçin,Ahmet Çetin +8 more
TL;DR: Some novel derivatives of thiosemicarbazide and 1,2,4‐triazole‐3‐thiol were synthesized and evaluated for their biological activities and the inhibitory effects of the target compounds against acetylcholinesterase, hCA I, and II were studied.
References
More filters
Journal ArticleDOI
Antituberculosis agents. I. Alpha-(5-(2-Furyl)-1,2,4-triazol-3-ylthio) acethydrazide and related compounds.
TL;DR: In this article, the authors have shown that α-15-(2-furyl)-1,2,4-triazol-3-ylthiol acethydrazide has significant activity against Myco tuberculosis.
Journal ArticleDOI
Synthesis of 5-membered heterocycles and related compounds.
Vishnuji Ram,Hridvanand Pandey +1 more
TL;DR: Some 1-(2, 4-dichlorophenoxy) acetyl-4-arylthiosemicarbazides were prepared from corresponding chlorophenoxyacetohydrazide and some of these compounds were evaluated as fungicides against Aspergillus niger.
Journal ArticleDOI
Bis‐heterocycles. Part III.: Synthesis of tetramethylene‐3,3′‐di‐1,2,4‐triazoles and tetramethylene‐2,2′‐di‐1,3,4‐thiadiazoles
Vishnu Ji Ram,H. N. Pandey +1 more
TL;DR: In this paper, tetramethylene-4,4′-bis(1-arylthiosemicarbazides) were converted into tetramylene-3,3′-,bis(4-aryl-5-mercapto-1,2,4-triazoles) and tetrammethylene-2,2′-bi[5-(arylamino)-1,3,4thiadiazoles] under different reaction conditions.