Journal ArticleDOI
Bizarre social behaviour in rats induced by a combination of a peripheral decarboxylase inhibitor and DOPA.
TLDR
Male rats given a combination of the peripheral DOPA decarboxylase inhibitor Ro 4-4602 and DOPA, showed motor excitation as well as a peculiar and bizarre pattern of social behaviour, and the possible role of brain dopamine in this social behaviour is discussed.About:
This article is published in European Journal of Pharmacology.The article was published on 1968-12-01. It has received 54 citations till now. The article focuses on the topics: Decarboxylase inhibitor & Aromatic L-amino acid decarboxylase.read more
Citations
More filters
Journal ArticleDOI
The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes.
TL;DR: It is hypothesized that the COMT Met allele (associated with low enzyme activity) results in increased levels of tonic DA and reciprocal reductions in phasic DA in subcortical regions and increased D1 transmission cortically.
Journal ArticleDOI
Intruder-evoked aggression in isolated and nonisolated mice: Effects of psychomotor stimulants and l -Dopa
TL;DR: D-Amphetamine, methamphetamine, methylphenidate, cocaine, and l-dopa decreased attack and threat behavior by resident mice, the isolates requiring 2–4 times higher drug doses for the antiaggressive effects than the nonisolates.
Journal ArticleDOI
Neurochemical and psychopharmacologic aspects of aggressive behavior.
TL;DR: Systematic alterations of central neurotransmitter activity in patients offer substantial promise of increasing the successful biological modification of violent behavior.
Book ChapterDOI
Mode of action of psychomotor stimulant drugs.
TL;DR: Evidence is available that the amphetamines act at neurons where catecholamines are transmitter substances, and Braindopamine in particular appears to have a predominant role in psychomotor stimulant action.
References
More filters
Journal Article
Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data?i. "neuroleptic activity spectra" for rats.
Journal ArticleDOI
Role of Catecholamines in the Amphetamine Excitatory Response
A. Randrup,I. Munkvad +1 more
TL;DR: The advent of α-methyl para-tyrosine3 (α-MPT), which inhibits the in vivo synthesis of 3,4-dihydroxyphenylalanine (DOPA)—the physiological precursor of the catecholamines—offers a new way of investigating this problem.
Journal Article
Cerebral accumulation and metabolism of C14-dopa after selective inhibition of peripheral decarboxylase.
G. Bartholini,A. Pletscher +1 more
TL;DR: It is concluded that Ro 4-4602 inhibits the decarboxylation of C 14 -dopa in extracerebral tissues rather selectively, which probably leads to an increased penetration of C 12 -dopamine from the blood into the brain, where it is then metabolized to C14 -catecholamines.
Journal Article
Effects of various centrally acting drugs on fighting behavior of mice.
TL;DR: A quantal type assay procedure was devised in an effort to study the effects of centrally active drugs on the frequency of fighting episodes and meprobamate exhibited a particular profile of activity which differentiated it from any of the other compounds studied.
Related Papers (5)
The effect of p-chlorophenylalanine on behavior in rats: relation to brain serotonin and 5-hydroxyindoleacetic acid
Stereotyped activities produced by amphetamine in several animal species and man.
A Randrup,I Munkvad +1 more