Bloodstream Infections Due to Trichosporon spp.: Species Distribution, Trichosporon asahii Genotypes Determined on the Basis of Ribosomal DNA Intergenic Spacer 1 Sequencing, and Antifungal Susceptibility Testing
Thomas C. Chagas-Neto,Guilherme Maranhão Chaves,Analy Salles de Azevedo Melo,Arnaldo Lopes Colombo +3 more
TLDR
A great diversity of different species causing trichosporonemia is found, including a high frequency of isolation of T. asteroides from blood cultures that is lower than that of T asahii only and the first T. asAHii isolate belonging to genotype 4 in South America is reported.Abstract:
The reevaluation of the genus Trichosporon has led to the replacement of the old taxon Trichosporon beigelii by six new species. Sequencing of the ribosomal DNA (rDNA) intergenic spacer 1 (IGS1) is currently mandatory for accurate Trichosporon identification, but it is not usually performed in routine laboratories. Here we describe Trichosporon species distribution and prevalence of Trichosporon asahii genotypes based on rDNA IGS1 sequencing as well as antifungal susceptibility profiles of 22 isolates recovered from blood cultures. The clinical isolates were identified as follows: 15 T. asahii isolates, five Trichosporon asteroides isolates, one Trichosporon coremiiforme isolate, and one Trichosporon dermatis isolate. We found a great diversity of different species causing trichosporonemia, including a high frequency of isolation of T. asteroides from blood cultures that is lower than that of T. asahii only. Regarding T. asahii genotyping, we found that the majority of our isolates belonged to genotype 1 (86.7%). We report the first T. asahii isolate belonging to genotype 4 in South America. Almost 50% of all T. asahii isolates exhibited amphotericin B MICs of ≥2 μg/ml. Caspofungin MICs obtained for all the Trichosporon sp. isolates tested were consistently high (MICs ≥ 2 μg/ml). Most isolates (87%) had high MICs for 5-flucytosine, but all of them were susceptible to triazoles, markedly to voriconazole (all MICs ≤ 0.06 μg/ml).read more
Citations
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Journal ArticleDOI
Atlas of Clinical Fungi
TL;DR: The atlas compiled by these editors is a commendable effort and welcome addition to the mycology textbook sector.
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Amphotericin B formulations: a comparative review of efficacy and toxicity.
TL;DR: The few comparative clinical trials that have been completed with the lipid-associated formulations have not demonstrated important clinical differences among these agents and amphotericin B for efficacy, although there are significant safety benefits of the lipid products.
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ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections
Maiken Cavling Arendrup,Teun Boekhout,Teun Boekhout,Teun Boekhout,Murat Akova,Jacques F. Meis,Oliver A. Cornely,O. Lortholary,O. Lortholary +8 more
TL;DR: Recommendations about the microbiological investigation and detection of invasive infection were made and current knowledge on the most appropriate antifungal and supportive treatment was reviewed.
Journal ArticleDOI
Current Knowledge of Trichosporon spp. and Trichosporonosis
TL;DR: Treating patients with trichosporonosis remains a challenge because of limited data on the in vitro and in vivo activities of antifungal drugs against clinically relevant species of the genus, but the use of antIfungal regimens containing triazoles appears to be the best therapeutic approach.
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Candida, Cryptococcus, and other yeasts of medical importance.
TL;DR: The chapter on Candida, Cryptococcus, and other yeasts of medical importance outlines the taxonomy, epidemiology, and clinical significance of species from as many as 12 yeast genera and contains five tables containing key identification characteristics of yeasts.
References
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John H. Rex,Clinical +1 more
TL;DR: A method for testing the susceptibility of antifungal agents to yeast that cause invasive fungal infections, including Candida spp.
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Yeasts: Characteristics and Identification
TL;DR: The most up-to-date yeast identification and reference manual as mentioned in this paper includes descriptions of the 678 currently recognised species and over 1300 high quality photomicrographs, and useful keys and tables allow identification of all of the species described.
Journal ArticleDOI
Atlas of Clinical Fungi
TL;DR: The atlas compiled by these editors is a commendable effort and welcome addition to the mycology textbook sector.
Journal ArticleDOI
Infections due to emerging and uncommon medically important fungal pathogens.
Thomas J. Walsh,Andreas H. Groll,John W. Hiemenz,Rhonda V. Fleming,Emmanuel Roilides,Elias Anaissie +5 more
TL;DR: The medical community is called upon to acquire an understanding of the microbiology, epidemiology and pathogenesis of these previously uncommon pathogens in order to become familiar with the options for prevention and treatment.