Journal ArticleDOI
Brain blood and cerebrospinal fluid flow dynamics during rhythmic handgrip exercise in young healthy men and women
Takashi Tarumi,Takashi Tarumi,Takashi Tarumi,Takayuki Yamabe,Takayuki Yamabe,Marina Fukuie,Marina Fukuie,David C. Zhu,Rong Zhang,Rong Zhang,Shigehiko Ogoh,Jun Sugawara,Jun Sugawara +12 more
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TLDR
In this article, the cerebral fluid response to exercise, including the arterial and venous cerebral blood flow (CBF) and cerebrospinal fluid (CSF), currently remains unknown.Abstract:
KEY POINTS The cerebral fluid response to exercise, including the arterial and venous cerebral blood flow (CBF) and cerebrospinal fluid (CSF), currently remains unknown. We used time-resolved phase-contrast magnetic resonance imaging to assess changes in CBF and CSF flow dynamics during moderate-intensity rhythmic handgrip (RHG) exercise in young healthy men and women. Our data demonstrated that RHG increases the cerebral arterial inflow and venous outflow while decreasing the pulsatile CSF flow during RHG. Furthermore, changes in blood stroke volume at the measured arteries, veins, and sinuses and CSF stroke volume at the cerebral aqueduct were positively correlated with each other during RHG. Male and female participants exhibited distinct blood pressure responses to RHG, but their cerebral fluid responses were similar. These results collectively suggest that RHG influences both CBF and CSF flow dynamics in a way that is consistent with the Monro-Kellie hypothesis to maintain intracranial volume-pressure homeostasis in young healthy adults. ABSTRACT Cerebral blood flow (CBF) increases during exercise, but its impact on cerebrospinal fluid (CSF) flow remains unknown. This study investigated CBF and CSF flow dynamics during moderate-intensity rhythmic handgrip (RHG) exercise in young healthy men and women. Twenty-six participants (12 women) underwent the RHG and resting control conditions in random order. Participants performed 3 sets of RHG, during which cine phase-contrast magnetic resonance imaging (PC-MRI) was performed to measure blood stroke volume (SV) and flow rate in the internal carotid (ICA) and vertebral (VA) arteries, the internal jugular vein (IJV), the superior sagittal (SSS) and straight sinuses (SRS), and CSF SV and flow rate in the cerebral aqueduct of Sylvius. Blood pressure, end-tidal CO2 (EtCO2 ), heart rate (HR), and respiratory rate were simultaneously measured during cine PC-MRI scans. Compared with control conditions, RHG showed significant elevations of HR, mean arterial pressure, and respiratory rate with a mild reduction of EtCO2 (all P < 0.05). RHG decreased blood SV in the measured arteries, veins, and sinuses and CSF SV in the aqueduct (all P < 0.05). Conversely, RHG increased blood flow in the ICA, VA, and IJV (all P < 0.05). At the aqueduct, RHG decreased the absolute CSF flow rate (P = 0.0307), which was calculated as a sum of the caudal and cranial CSF flow rates. Change in the ICA SV was positively correlated with changes in the IJV, SSS, SRS, and aqueductal SV during RHG (all P < 0.05). These findings demonstrate a close coupling between the CBF and CSF flow dynamics during RHG in young healthy adults.read more
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Sympathoexcitatory Responses to Isometric Handgrip Exercise Are Associated With White Matter Hyperintensities in Middle-Aged and Older Adults
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References
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Journal ArticleDOI
Effects of aging, sex, and physical training on cardiovascular responses to exercise.
T. Ogawa,Robert J. Spina,Wade H. Martin,Wendy M. Kohrt,K B Schechtman,John O. Holloszy,Ali A. Ehsani +6 more
TL;DR: A lower stroke volume, heart rate, and arteriovenous oxygen difference at maximal exercise all contribute to the age-related decline in V˙o2max.
Journal ArticleDOI
Cardiovascular Flow Measurement with Phase-Contrast MR Imaging: Basic Facts and Implementation
TL;DR: With phase-contrast imaging, the overall error in flow measurement can be reduced to less than 10%, an acceptable level of error for routine clinical use.
Journal ArticleDOI
Mechanisms of fluid movement into, through and out of the brain: evaluation of the evidence
TL;DR: Flow rates measured using phase contrast magnetic resonance imaging reveal CSF movements to be more rapid and variable than previously supposed, even implying that under some circumstances net flow through the cerebral aqueduct may be reversed with net flow into the third and lateral ventricles.
Journal ArticleDOI
Physical Activity, Cognition, and Brain Outcomes: A Review of the 2018 Physical Activity Guidelines.
Kirk I. Erickson,Charles H. Hillman,Chelsea M. Stillman,Rachel M. Ballard,Bonny Bloodgood,David E. Conroy,Richard F. Macko,David X. Marquez,Steven J. Petruzzello,Kenneth E. Powell +9 more
TL;DR: There is moderate-to-strong support that PA benefits cognitive functioning during early and late periods of the life span and in certain populations characterized by cognitive deficits.
Journal ArticleDOI
Meningeal lymphatic vessels at the skull base drain cerebrospinal fluid
Ji-Hoon Ahn,Hyunsoo Cho,Jun-Hee Kim,Shin Heun Kim,Je-Seok Ham,Intae Park,Sang Heon Suh,Seon Pyo Hong,Joo Hye Song,Young-Kwon Hong,Yong Jeong,Sung-Hong Park,Gou Young Koh +12 more
TL;DR: The importance of meningeal lymphatic vessels in the basal part of the skull for CSF clearance is revealed by visualizing their distinct anatomical location and characterizing their specialized morphological features, which facilitate the uptake and drainage of CSF.