Brain monoamines and adrenocortical activation.
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TLDR
No strict correlation was found between the depletion of brain amine stores induced by prenylamine or p‐chlorophenylalanine and adrenocortical activation, even at times in which the peak effect ofbrain amine depletion occurs.Abstract:
1. The effect of a pharmacologically induced increase or depletion of brain monoamines (5-hydroxytryptamine, noradrenaline, dopamine) was investigated with respect to adrenocortical function.
2. No strict correlation was found between the depletion of brain amine stores induced by prenylamine or p-chlorophenylalanine and adrenocortical activation, even at times in which the peak effect of brain amine depletion occurs.
3. Restraint stress causes a manifest increase in brain 5-hydroxytryptamine while decreasing the cerebral noradrenaline and dopamine content. This stress strongly stimulates corticosterone secretion by the adrenals.
4. A monoamine oxidase inhibitor, nialamide, at a dose which causes an evident increase in brain amine concentrations, does not modify plasma corticosterone. At the same dose it was, furthermore, unable to prevent the adrenocortical stimulation induced by restraint stress.
5. Brain amine content does not seem to play an important part in the control of corticotrophin releasing factor in corticotrophin secretion by the pituitary gland. The relationship between hypothalamic monoamines and other neurohumours is discussed.read more
Citations
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Stress-induced depression of motor activity correlates with regional changes in brain norepinephrine but not in dopamine
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Plasma corticosterone and brain catecholamines in stress: Effect of psychotropic drugs
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References
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TL;DR: By the addition of small amounts of ethylene diamine (EDA) to the alkali-ascorbic acid mixture used in the trihydroxyindole (THI) method the discoloration of reaction mixture and instability of fluorescence can be prevented, allowing blanks to maintain their fluorescence values for several hours.
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TL;DR: A fluorimetric method for the determination of dopamine using differences in fluorescence characteristics at pH about 5.3, microquantities of dopainine can be determined in the presence of at least equal amounts of adrenaline or noradrenaline.