Brain temperature homeostasis: physiological fluctuations and pathological shifts.
Reads0
Chats0
TLDR
Since high temperature could irreversibly damage neural cells and worsen various pathological processes, the situations associated with pathological brain hyperthermia are considered and its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration is evaluated.Abstract:
Brain temperature is a physiological parameter, reflecting the balance between metabolism-related intra-brain heat production and heat loss by cerebral circulation to the rest of the body and then to the external environment. First, we present data on brain temperature fluctuations occurring under physiological and behavioral conditions and discuss their mechanisms. Since most processes governing neural activity are temperature-dependent, we consider how naturally occurring temperature fluctuations could affect neural activity and neural functions. We also consider psychomotor stimulants and show that their hyperthermic effects are state-dependent and modulated by environmental conditions. Since high temperature could irreversibly damage neural cells and worsen various pathological processes, we consider the situations associated with pathological brain hyperthermia and evaluate its role in acute perturbations of brain functions, neurotoxicity, and neurodegeneration. We also discuss the limitations in consideration of brain temperature within the frameworks of physiological regulation and homeostasis. While different adaptive mechanisms could, within some limits, compensate for altered intra-brain heat balance, these mechanisms could fail in real-life situations, resulting in life-threatening health complications.read more
Citations
More filters
Journal ArticleDOI
Interpreting EEG alpha activity
O. M. Bazanova,David Vernon +1 more
TL;DR: This review attempts to delineate EEG alpha-activity, its physical, molecular and morphological nature, and examines the following indices: (1) the individual alpha peak frequency; (2) activation magnitude; and (3) alpha "auto-rhythmicity" indices: which include intra-spindle amplitude variability, spindle length and steepness.
Journal ArticleDOI
Brain temperature and its fundamental properties: a review for clinical neuroscientists.
Huan Wang,Huan Wang,Bonnie H. Wang,Kieran P. Normoyle,Kieran P. Normoyle,Kevin S. Jackson,Kevin Spitler,Matthew F. Sharrock,Claire M. Miller,Catherine Best,Daniel A. Llano,Daniel A. Llano,Rose Du +12 more
TL;DR: This review discusses several critical aspects concerning the fundamental properties of brain temperature from a clinical perspective and discusses the mechanism underlying brain thermal homeostasis.
Journal ArticleDOI
Thermoregulatory disorders and illness related to heat and cold stress.
TL;DR: The clinical detection of thermoregulatory impairment provides important diagnostic and localizing information in the evaluation of disorders that impair thermoreGulatory pathways, including autonomic neuropathies and ganglionopathies.
Journal ArticleDOI
Temperature and neuronal circuit function: compensation, tuning and tolerance.
TL;DR: Prior experience of temperature extremes activates conserved processes of phenotypic plasticity that tune neuronal circuits to be better able to withstand the effects of temperature and to recover more rapidly from failure.
Journal ArticleDOI
Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl.
TL;DR: The development of substrate‐specific sensors coupled with amperometry made it possible to directly evaluate physiological and drug‐induced fluctuations in brain oxygen levels in awake, freely‐moving rats, and these data have clear human relevance in addressing the alarming rise in lethality associated with the opioid abuse.
References
More filters
Journal ArticleDOI
The Blood-Brain Barrier in Health and Chronic Neurodegenerative Disorders
TL;DR: These findings support developments of new therapeutic approaches for chronic neurodegenerative disorders directed at the blood-brain barrier and other nonneuronal cells of the neurovascular unit.
Journal ArticleDOI
Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects.
Peter T. Fox,Marcus E. Raichle +1 more
TL;DR: Dynamic, physiological regulation of CBF by a mechanism (neuronal or biochemical) dependent on neuronal firing per se, but independent of the cerebral metabolic rate of oxygen, is hypothesized.
Journal ArticleDOI
The Pharmacology and Clinical Pharmacology of 3,4-Methylenedioxymethamphetamine (MDMA, “Ecstasy”)
TL;DR: Evidence for the occurrence of MDMA-induced neurotoxic damage in human users remains equivocal, although some biochemical and functional data suggest that damage may occur in the brains of heavy users.
Journal ArticleDOI
The metabolic cost of neural information
TL;DR: Biophysical measurements from cells in the blowfly retina yield estimates of the energy required to generate graded (analog) electrical signals that transmit known amounts of information, which promotes the distribution of information among multiple pathways.