Journal ArticleDOI
Breast-Conserving Treatment With or Without Radiotherapy in Ductal Carcinoma-In-Situ: Ten-Year Results of European Organisation for Research and Treatment of Cancer Randomized Phase III Trial 10853—A Study by the EORTC Breast Cancer Cooperative Group and EORTC Radiotherapy Group
Nina Bijker,Philip Meijnen,Johannes L. Peterse,Jan Bogaerts,Irène Van Hoorebeeck,J.P. Julien,Massimiliano Gennaro,Philippe Rouanet,Antoine Avril,Ian S. Fentiman,H. Bartelink,Emiel J Th Rutgers +11 more
TLDR
With long-term follow-up, RT after LE for DCIS continued to reduce the risk of LR, with a 47% reduction at 10 years, and all patient subgroups benefited from RT.Abstract:
Purpose The European Organisation for Research and Treatment of Cancer conducted a randomized trial investigating the role of radiotherapy (RT) after local excision (LE) of ductal carcinoma-in-situ (DCIS) of the breast. We analyzed the efficacy of RT with 10 years follow-up on both the overall risk of local recurrence (LR) and related to clinical, histologic, and treatment factors.read more
Citations
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NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines
TL;DR: Lymphedema is a common complication after treatment for breast cancer and factors associated with increased risk of lymphedEMA include extent of axillary surgery, axillary radiation, infection, and patient obesity.
Journal ArticleDOI
Progress and promise: highlights of the international expert consensus on the primary therapy of early breast cancer 2007
A. Goldhirsch,William C. Wood,Richard D. Gelber,Alan S. Coates,Beat Thürlimann,H.-J. Senn,Panel Members +6 more
TL;DR: An expert Panel reaffirmed the primary importance of determining endocrine responsiveness of the cancer as a first approach to selecting systemic therapy and recommended the use of high-quality standard histopathological assessment for both risk allocation and target identification.
Journal ArticleDOI
Long-Term Outcomes of Invasive Ipsilateral Breast Tumor Recurrences After Lumpectomy in NSABP B-17 and B-24 Randomized Clinical Trials for DCIS
Irene Wapnir,James J. Dignam,Bernard Fisher,Eleftherios P. Mamounas,Stewart J. Anderson,Thomas B. Julian,Stephanie R. Land,Richard G. Margolese,Sandra M. Swain,Joseph P. Costantino,Norman Wolmark +10 more
TL;DR: Although I-IBTR increased the risk for breast cancer-related death, radiation therapy and tamoxifen reduced I- IBTR, and long-term prognosis remained excellent after breast-conserving surgery for DCIS.
Journal ArticleDOI
Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast
C Correa,Paul McGale,Carolyn W. Taylor,Yaochen Wang,Mike Clarke,C Davies,Richard Peto,N Bijker,L Solin,Sarah C. Darby +9 more
TL;DR: Radiotherapy reduced the absolute 10-year risk of any ipsilateral breast event (ie, either recurrent DCIS or invasive cancer) by 15.2% and was effective regardless of the age at diagnosis, extent of breast-conserving surgery, use of tamoxifen, method of DCIS detection, margin status, focality, grade, comedonecrosis, architecture, or tumor size.
Journal ArticleDOI
Ductal carcinoma in situ of the breast: a systematic review of incidence, treatment, and outcomes.
TL;DR: In this paper, a structured literature review on the incidence, treatment, and outcomes of ductal carcinoma in situ (DCIS) was presented as a background article for the State of the Science Conference on Diagnosis and Management of DCIS.
References
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Book ChapterDOI
Nonparametric Estimation from Incomplete Observations
Edward L. Kaplan,Paul Meier +1 more
TL;DR: In this article, the product-limit (PL) estimator was proposed to estimate the proportion of items in the population whose lifetimes would exceed t (in the absence of such losses), without making any assumption about the form of the function P(t).
Book ChapterDOI
Regression Models and Life-Tables
TL;DR: The analysis of censored failure times is considered in this paper, where the hazard function is taken to be a function of the explanatory variables and unknown regression coefficients multiplied by an arbitrary and unknown function of time.
Journal Article
Evaluation of survival data and two new rank order statistics arising in its consideration.
Journal ArticleDOI
Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer.
Bernard Fisher,Stewart J. Anderson,John Bryant,Richard G. Margolese,Melvin Deutsch,Edwin R. Fisher,Jong-Hyeon Jeong,Norman Wolmark +7 more
TL;DR: Lumpectomy followed by breast irradiation continues to be appropriate therapy for women with breast cancer, provided that the margins of resected specimens are free of tumor and an acceptable cosmetic result can be obtained.
Journal ArticleDOI
Long-Term Results of a Randomized Trial Comparing Breast-Conserving Therapy With Mastectomy: European Organization for Research and Treatment of Cancer 10801 Trial
Joop A. van Dongen,Adri C. Voogd,Ian S. Fentiman,Catherine Legrand,Richard Sylvester,D. Tong,Emmanuel van der Schueren,Peter A. Helle,Kobus van Zijl,Harry Bartelink +9 more
TL;DR: BCT and mastectomy demonstrate similar survival rates in a trial in which the great majority of the patients had stage II breast cancer, and the rate of locoregional recurrence at 10 years did show a statistically significant difference.