Breastfeeding and transmission of cytomegalovirus to preterm infants. Case report and kinetic of CMV-DNA in breast milk
Manuela Chiavarini,Patrizia Bragetti,Alessandra Sensini,Elio Cenci,Roberto Castronari,Marta J Rossi,Ambra Fantauzzi,Liliana Minelli +7 more
TLDR
Only one infant was infected by CMV, developing hepatic affection concomitantly with a multi-system involvement, as shown CMV DNA detection in urine, saliva, blood, gastric aspirate, and stools.Abstract:
Background
Breastfeeding has a major impact on CMV epidemiology. Postnatal CMV reactivation's incidence during lactation is nearby the maternal seroprevalence. Although perinatal CMV infection has practically no consequences in term newborn, it may cause, in some cases, a severe symptomatic disease in preterm newborns.
The aims of the present study are to evaluate the rate and clinical expression of CMV infection breast milk transmitted in preterm infants and to check the safety of the freezing treated breast milk.read more
Citations
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Breast Milk–Acquired Cytomegalovirus Infection and Disease in VLBW and Premature Infants
Tatiana M. Lanzieri,Sheila C. Dollard,Cassandra D. Josephson,D. Scott Schmid,Stephanie R. Bialek +4 more
TL;DR: Prospective studies to better define the burden of disease are needed to refine guidelines for feeding breast milk from CMV-seropositive mothers to VLBW and premature infants.
Journal ArticleDOI
Prevention of Transfusion-Acquired Cytomegalovirus Infections in Newborn Infants
Anne S. Yeager,F. Carl Grumet,Elizabeth B. Hafleigh,Ann M. Arvin,John S. Bradley,Charles G. Prober +5 more
TL;DR: Use of seronegative donors reduced the prevalence of excretion of CMV among hospitalized infants who were 4 weeks of age or older from 12.5 to 1.8% and eliminated acquired CMV infections in infants of ser onegative mothers.
Journal ArticleDOI
Postnatal Cytomegalovirus Infection Through Human Milk in Preterm Infants: Transmission, Clinical Presentation, and Prevention.
Klaus Hamprecht,Rangmar Goelz +1 more
TL;DR: Short-term heat inactivation for 5 minutes at 62°C maintains the benefits of feeding BM without the disadvantages of CMV transmission; this can be applied effectively under routine conditions.
Journal ArticleDOI
Breast milk-acquired cytomegalovirus infection in very low birth weight infants
TL;DR: Perinatal transmission of human cytomegalovirus (HCMV) infection in very low birth weight (VLBW) premature infants can lead to serious clinical symptoms and it has ben increasingly recognized that breast milk is the most frequent route of transmission.
Journal ArticleDOI
High-Temperature Short-Time Pasteurization System for Donor Milk in a Human Milk Bank Setting.
Diana Escuder-Vieco,Irene Espinosa-Martos,Juan M. Rodríguez,Nieves Corzo,Antonia Montilla,Pablo Siegfried,Carmen Rosa Pallás-Alonso,Leónides Fernández +7 more
TL;DR: Processing of donor milk at 72°C for at least 10 s in this HTST system allows to achieve the microbiological safety objectives established in the milk bank while having a lower impact regarding the heat damage of the milk.
References
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Journal ArticleDOI
Effect of breastfeeding on infant and child mortality due to infectious diseases in less developed countries: a pooled analysis.
TL;DR: A pooled analysis of studies that assessed the effect of not breastfeeding on the risk of death due to infectious diseases in Africa found that protection provided by breastmilk declined steadily with age during infancy, and protection was highest when maternal education was low.
Journal ArticleDOI
Prevention of transfusion-acquired cytomegalovirus infections in newborn infants
Anne S. Yeager,F. Carl Grumet,Elizabeth B. Hafleigh,Ann M. Arvin,John S. Bradley,Charles G. Prober +5 more
TL;DR: Use of seronegative donors reduced the prevalence of excretion of CMV among hospitalized infants who were 4 weeks of age or older from 12.5 to 1.8% and eliminated acquired CMV infections in infants of ser onegative mothers.
Journal ArticleDOI
Epidemiology of transmission of cytomegalovirus from mother to preterm infant by breastfeeding
TL;DR: The proportion of cytomegalovirus reactivation during lactation almost equals maternal seroprevalence, which has been underestimated and may be associated with a symptomatic infection.
Journal ArticleDOI
Quantitation of Cytomegalovirus: Methodologic Aspects and Clinical Applications
Michael Boeckh,Guy Boivin +1 more
TL;DR: In this paper, the authors discuss methodological aspects of currently used quantitative assays for cytomegalovirus (CMV) (i.e., viral culture techniques, antigen detection, DNA detection assays including PCR, branched-DNA assay, and the DNA hybrid capture assay) and address the correlation of systemic and site-specific CMV load and CMV disease in different populations of immunosuppressed patients as well as the response to antiviral treatment.
Journal ArticleDOI
Cytomegalovirus Infection of Breast Milk and Transmission in Infancy
TL;DR: The possibility that an unnecessary and perhaps more severe illness might occur in low-birth-weight seronegative infants fed banked human milk from sources other than the mother is disturbing and needs resolution.