Open AccessJournal Article
Bridging peripheral nerve defect with chitosan-collagen film.
Xin Wei,Jie Lao,Yu-dong Gu +2 more
TLDR
Chitosan-collagen film conduit can be used to bridge peripheral nerve defect and the quality of nerve regeneration was similar to that of the control group.Abstract:
Objective: To seek new method for the treatment of peripheral nerve injury. Methods: In rat model with sciatic nerve defect, chitosan collagen film was sutured into conduit to bridge 5 mm , 10 mm nerve defects. Rats that underwent end to end anastomosis were taken as controls. General observation, electrophysiological study, histological study and image analysis were performed at 4, 8, 12 weeks postoperatively. Results: In 5 mm nerve defects, the quality of nerve regeneration was similar to that of the control group. For 10 mm nerve defect, nerve regeneration was inferior to that of the control group. Chitosan collagen film obviously degraded at 12 weeks postoperatively. Conclusions: Chitosan collagen film conduit can be used to bridge peripheral nerve defect.read more
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New hemostatic agents in the combat setting.
E. Darrin Cox,E. Darrin Cox,Martin A. Schreiber,Martin A. Schreiber,John G. McManus,John G. McManus,Charles E. Wade,Charles E. Wade,John B. Holcomb,John B. Holcomb +9 more
TL;DR: Clinical observations are reported regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism.
Book ChapterDOI
The use of chitosan-based scaffolds to enhance regeneration in the nervous system.
S. Gnavi,Christina Barwig,Thomas Freier,Kirsten Haastert-Talini,Claudia Grothe,Stefano Geuna +5 more
TL;DR: The promising in vitro and in vivo experimental results make it possible to foresee that time for clinical trials with chitosan-based nerve regeneration-promoting devices is approaching quickly.
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Relevance and Recent Developments of Chitosan in Peripheral Nerve Surgery
TL;DR: An overview on the physiologic properties of chitosan is given to evaluate its effect on peripheral nerve regeneration and discuss the future translation into clinical practice.
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Non-surgical therapies for peripheral nerve injury
TL;DR: Non-surgical approaches to enhance nerve recovery, which are complementary to surgery and are an adjunct to the reinnervation process, and the hypotheses proved in animals and in vitro should be translated to human clinical practice.
Journal ArticleDOI
Ultrastructural analysis of guided nerve regeneration using progesterone- and pregnenolone-loaded chitosan prostheses.
María Estela Chávez-Delgado,Ulises Gómez-Pinedo,Alfredo Feria-Velasco,M. Huerta-Viera,S. Castro Castañeda,F. A. López-Dellamary Toral,A. Parducz,S. Luquín-De Anda,J. Mora-Galindo,Joaquín García-Estrada +9 more
TL;DR: It is indicated that chitosan prostheses allowed regeneration of nerve fibers in their lumen, and when containing neurosteroids produced a faster guided nerve regeneration acting as a long-lasting release delivery vehicle.