Journal ArticleDOI
Bronchodilator responsiveness using spirometry in healthy and asthmatic preschool children
Luís Miguel Borrego,Janet Stocks,Isabel Almeida,Sanja Stanojevic,Sanja Stanojevic,João Antunes,Paula Leiria-Pinto,José Rosado-Pinto,Ah Fong Hoo +8 more
TLDR
BDR can be assessed reliably using FEV0.75 in wheezy preschoolers, provided within-subject variability and responsiveness in health are taken into consideration.Abstract:
Objective To assess repeatability and reproducibility of spirometry measurements, and bronchodilator responsiveness (BDR), in healthy 3–6-year-old preschool children and those with asthma. Design Spirometry was performed before and 20 minutes after administering either inhaled placebo (for repeatability) or 400 μg salbutamol (for BDR) on two separate occasions (reproducibility) 3–23 days apart in asthmatic preschoolers and healthy controls. Settings Lung Function Laboratory, Hospital de Dona Estefania, Lisbon. Participants Healthy preschool children and those with physician-diagnosed asthma, recruited from local Health Clinics and Outpatient Clinic. Main outcome measures Paired measurements of forced expired volume in 0.75 s (FEV0.75) and forced midexpiratory flows (FEF25–75). Results Technically successful baseline results were obtained in 86% of children assessed. Paired data were obtained in 43 asthmatic and 22 controls (median (range) age: 5.1 (3.4–6.8) years). Baseline FEV0.75 was significantly lower in asthmatic children (mean (SD): 90 (15)% predicted) than in controls (102 (13) % predicted; p<0.001). Withinoccasion coefficient of repeatability following placebo was similar in both groups, being 10.4% in asthma and 13.2% in controls for FEV0.75. Following bronchodilator, FEV0.75 increased significantly more in asthmatic preschoolers (mean (SD): 15.0 (12) %) than in controls (4.5 (5) %; p<0.001), with no significant difference between groups post-bronchodilator. Between-occasion variability was similar to within-day repeatability in controls, but almost twice as high in asthmatic children. Conclusions BDR can be assessed reliably using FEV0.75 in wheezy preschoolers, provided within-subject variability and responsiveness in health are taken into consideration.read more
Citations
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Journal ArticleDOI
Assessing bronchodilator response in preschool children using spirometry
TL;DR: A negative BDR in a child suspected of having asthma makes a diagnosis of asthma less likely and the within-session repeatability and receiver operating characteristic curve analyses were used to determine the optimal threshold values for BDR.
Journal ArticleDOI
Forced expiratory flows’ contribution to lung function interpretation in schoolchildren
Bernard Boutin,Marc Koskas,Houda Guillo,Lucia Maingot,Marie-Claude La Rocca,Michèle Boulé,Jocelyne Just,Isabelle Momas,Alberti Corinne,Nicole Beydon +9 more
TL;DR: Examining whether FEF results could modify the interpretation of baseline and post-bronchodilator spirometry in asthmatic schoolchildren in whom forced expiratory volumes are within the normal range found it unlikely that results would alter the quality of spirometry quality in healthy children.
Journal ArticleDOI
The bronchodilator response in preschool children: A systematic review.
TL;DR: There is little evidence‐based guidance describing the role of BDR testing in preschool children and it is unclear whether published cut‐off values, which are derived from adult data, can be applied to this population.
Journal ArticleDOI
Lung clearance index and steroid response in pediatric severe asthma.
Samantha Irving,Louise Fleming,Fatima Ahmad,Elizabeth Biggart,Yvvone Bingham,James Cook,Pippa Hall,Angela Jamalzadeh,Prasad Nagakumar,Cara Bossley,Cara Bossley,Atul Gupta,Atul Gupta,Kenneth A Macleod,Sejal Saglani,Andrew Bush +15 more
TL;DR: This data indicates that lung clearance index would be higher (worse) in children with severe therapy‐resistant asthma (STRA) compared with difficult asthma and healthy controls and that LCI would fall in response to parenteral steroids in STRA.
Journal ArticleDOI
Assessment of Airway Bronchodilation by Spirometry Compared to Airway Obstruction in Young Children with Asthma
TL;DR: The response of spirometry parameters to bronchodilators may be more sensitive than obstruction detection and may help to support the diagnosis of asthma and adjust treatment plan.
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An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children.
Nicole Beydon,Stephanie D. Davis,Enrico Lombardi,Julian L. Allen,Hubertus G.M. Arets,Paul Aurora,Hans Bisgaard,G. Michael Davis,Francine M. Ducharme,Howard Eigen,Monika Gappa,Claude Gaultier,P. Gustafsson,Graham L. Hall,Zoltán Hantos,Michael J. R. Healy,Marcus Herbert Jones,Bent Klug,Karin C. Lødrup Carlsen,Sheila A. McKenzie,Francçois Marchal,Oscar H. Mayer,Peter J. F. M. Merkus,Mohy G. Morris,Ellie Oostveen,J. Jane Pillow,Paul Seddon,Michael Silverman,Peter D. Sly,Janet Stocks,Robert S. Tepper,Daphna Vilozni,Nicola Wilson +32 more
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