Calculated equilibria of phosphocreatine and adenosine phosphates during utilization of high energy phosphate by muscle.
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TLDR
The equations have been used to calculate the expected concentrations of free ATP, ADP, and AMP as high energy phosphate is discharged by a representative muscle, and physiological changes in pH are sufficient to cause significant changes in the rate of glycolysis in this way.About:
This article is published in Journal of Biological Chemistry.The article was published on 1974-09-25 and is currently open access. It has received 130 citations till now. The article focuses on the topics: Phosphocreatine & Creatine kinase.read more
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Cytosolic phosphorylation potential.
TL;DR: Agreement between two highly active enzyme systems in the same compartment is taken as evidence of the existence of near-equilibrium in both these systems and suggests that free cytosolic [sigma ADP] is probably 20-fold lower than measured cell ADP content in mitochondrial-containing tissues.
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A simple analysis of the "phosphocreatine shuttle"
TL;DR: Experimental results demonstrating the transport aspects of the CK reaction emphasize only one feature of a more general notion of facilitated diffusion by near-equilibrium metabolic reactions and do not per se establish the existence of any physical or functional compartmentation of ATP, ADP, PCr, or creatine.
Journal ArticleDOI
Evolution and physiological roles of phosphagen systems
TL;DR: It is hypothesized that the capacity for intracellular targeting of CK evolved early as a means of facilitating energy transport in highly polarized cells and was subsequently exploited for temporal ATP buffering and dynamic roles in metabolic regulation in cells displaying high and variable rates of aerobic energy production.
Journal ArticleDOI
Metabolic recovery after exercise and the assessment of mitochondrial function in vivo in human skeletal muscle by means of 31P NMR.
TL;DR: It is concluded that the calculated rate of recovery of the cytosolic free [ADP] to its pre‐exercise concentration may provide a more specific measure of mitochondrial oxidative activity.
References
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Effect of pH on the Kinetics of Frog Muscle Phosphofructokinase
TL;DR: It is concluded that shifts in intracellular pH are important in the regulation of phosphofructokinase, but that this effect makes interpretation of data from intact muscle quite difficult.
Journal ArticleDOI
Phosphofructokinase and the Pasteur effect.
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