Journal ArticleDOI
Cancer growth, response to treatment and survival time in mice: beneficial effect of the prostaglandin synthesis inhibitor flurbiprofen.
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TLDR
Daily treatment with flurbiprofen starting before injection of the cancer cells reduced tumour growth and lengthened the survival of mice whose tumours were excised at 3 weeks.About:
This article is published in Prostaglandins.The article was published on 1979-02-01. It has received 99 citations till now. The article focuses on the topics: Cancer & Flurbiprofen.read more
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Aspirin Use and Risk of Fatal Cancer
TL;DR: The data suggest that regular, prolonged use of aspirin may reduce the risk of fatal cancer of the esophagus, stomach, colon, and rectum and future epidemiological and basic research should examine all digestive tract cancers.
Journal Article
Aspirin and the Potential Role of Prostaglandins in Colon Cancer
TL;DR: This Perspective was written to highlight some of the existing literature on the aspirin-inhibitable branch of the arachidonic acid cascade and cancer, to apply that liter ature to colon cancer where possible, and to identify deficien cies in knowledge that need to be addressed.
Journal ArticleDOI
Regulation of the immune response by prostaglandins.
TL;DR: A substantial body of evidence implicates prostaglandins E1 and E2 as local feedback inhibitors of T-cell activation in vitro and in vivo and results in an enhanced cellular immune response in a number of different experimental systems.
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Regulation of the immune response by prostaglandins
James S. Goodwin,Jan Ceuppens +1 more
TL;DR: Of all the arachidonic acid metabolites, only prostaglandin E (PGE) has been shown to have a clear role in the regulation of cellular and humoral immune responses.
Journal ArticleDOI
Sulindac for polyposis of the colon.
TL;DR: Four members of a Gardner's syndrome family had rectal and colon polyposis treated with nonsteroid anti‐inflammatory drugs and the residual polyps arose in the rectal mucosa and almost completely disappeared when sulindac was administered.
References
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Journal ArticleDOI
Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.
Richard Peto,M.C. Pike,P. Armitage,N. E. Breslow,David Cox,S V Howard,N Mantel,Klim McPherson,Julian Peto,Pete Smith +9 more
TL;DR: Efficient methods of analysis of randomized clinical trials in which the authors wish to compare the duration of survival among different groups of patients are described.
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A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin
H B Hewitt,E R Blake,A S Walder +2 more
TL;DR: It is suggested that isotransplants of spontaneously arising tumours are the only appropriate models of human cancer and that any genuine rapport between the animal laboratory and the clinic requires their exclusive use.
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Prostaglandins as Mediators of Hypercalcemia Associated with Certain Types of Cancer
TL;DR: Inhibition of prostaglandin synthesis by aspirin or indomethacin reduced excretion of both the urinary metabolite and serum calcium in six hypercalcemic patients with solid tumors and elevated excretionOf the metabolite.
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Subversion of immune system by tumor cells and role of prostaglandins
TL;DR: The findings suggest that tumors, although antigenic, may be able to escape immuno-sureillance by their host by means of subverting the immune system, and success of immunotherapy may well depend on the ability to prevent or block the immunosuppressive activity of tumors.